Dm meds fill in blanks

Question 1

metformin is a _____ (drug class) that works at the _______ to _______ gluconeogenesis and _________ resistance. this med ______ require functional beta cells

Answer 1

• biguanide
• liver
• decrease
• insulin resistance
• DOES NOT

Question 2

“mides, rides, and zides” belong to the drug class _______ and work at the ______ to mimic _______ and therefore increase _______ secretion from _________

Answer 2

• SULFONYLUREAS
• pancreas
• glucose
• insulin
• beta cells of pancreas

Question 3

“glitazones” belong to the drug class ________ and work at the _______ to increase _________ which therefore decreases ___________

Answer 3

• thiazolidinediones “TZDs”
• nucleus
• insulin sensitivity
• insulin resistance

***does NOT require functional beta cells

Question 4

“tides” belong to the drug class _______ and work at the _______ to increase ___________ and decrease _________ which delays _______ and improves ________

Answer 4

• GLP-1 receptor agonists
• pancreas
• insulin secretion
• glucagon secretion
• gastric emptying
• post-prandial hyperglycemia

Question 5

alpha-gluosidase inhibitors include the two drugs ______ and work at the ______ to decrease _______ absorption which slows absorption of _______ which decreases _______

Answer 5

• acarbose & miglitol
• intestine
• glucose
• carbs
• post-prandial hyperglycemia

Question 6

“gliptins” belong to the drug class _______ and works at the ______ to increase ______ and decrease _______

Answer 6

• DPP4- inhibitors
• pancreas
• increase insulin
• decrease glucose

Question 7

“gliflozins” belong to the drug class ______ and work at the ______ to increase ________

Answer 7

• SGLT-2 inhibitors
• proximal renal tubule
• renal glucose excretion

Question 8

this med increases risk for CHF

Answer 8

pioglitazone (TZD)

Question 9

this class of PO meds must be taken with meals and include the two drugs _________

Answer 9

• alpha-glucosidase inhibitors

* acarbose & miglitol

Question 10

this med has a black box warning for thyroid cancer

Answer 10

GLP-1 receptor agonists

Question 11

GLP-1 receptor agonists AND DPP4-inhibs have a side effect of _______ and therefore is not good for _______

Answer 11

• pancreatitis

* binge drinkers

Question 12

this class of meds if started early can spare damage to beta cells

Answer 12

*GLP-1 receptor agonists

Question 13

this class of meds are associated with increased risk for elderly mortality

Answer 13

sulfonylureas

Question 14

“IDEs” belong to which class

Answer 14

SULFAs

• tolbutaMIDE
• chlorpropaMIDE
• glybuRIDE
• glimepeRIDE

*glipiZIDE

Question 15

which two GLP-1s have ASCVD & CHF benefits?

Answer 15

• exenatide (byetta)
• liraglutide (victoza)
• none of the other ones have specific benefits

Question 16

which two SGLT-2 inhibitors are associated with increased risk of bone fracture?

Answer 16

• canaGLIFLOZIN

* empaGLIFLOZIN

Question 17

SGLT-2 inhibitors work at the?

Answer 17

proximal renal tubule

Question 18

DPP4-inhibitors work at the?

Answer 18

pancreas

Question 19

GLP-1 receptor agonists work at the?

Answer 19

pancreas

Question 20

alpha-glucosidase inhibitors work at the?

Answer 20

intestine

Question 21

TZDs work at the?

Answer 21

nucleas

Question 22

sulfons work at the?

Answer 22

pancreas

Question 23

metformin works at the?

Answer 23

liver

Question 24

which med has a Black box warning for amputation?

Answer 24

canaGLIFLOZIN

Question 25

which DDP4-inhibitor has an increased risk for CHF?

Answer 25

saxagliptin

Question 26

which two classes of drugs causes weight gain?

Answer 26

SULFONs & TZDs