DM/hypoglycemia Flashcards
which deficiency can cause falsely elevated a1c
iron deficiency
effect of proteinuria on fructosamine levels
falsely decreased fructosamine (high albumin turnover)
fructosamine to a1c ratio
fructosamine should be ~40x higher than a1c
target glucose levels during pregnancy
fasting < 95
1hr postprandial < 140
2hr postprandial < 120
3 most common MODYs
MODY 3
MODY 2
MODY 1
treatment of MODY 3/1
sulfonylurea
fructosamine provides an estimate of glucose levels over what time frame
1-2 weeks
which SGLT2i has increased rate of fractures
canagliflozin
which SGLT2i have warnings regarding limb amputations
canagliflozin
sertugliflozin
which SGLT2i has warning regarding bladder cancer
dapagliflozin
how many type 2 DM patients have LADA?
~30%
criteria for LADA
age > 30
+ antibodies
not requiring insulin for > 6 months
u500 candidates
> 200 units per day of insulin
DM autoantibodies
GAD 65 Islet cell ab Insulinoma associated autoantibody Insulin ab ZnT8 transporter
what % of ab negative DMt1 has ZnT8 ab?
26%