DM drugs Flashcards
Biguanide
Metformin
Metformin SOA
Liver
When to not use metformin
GFR <30 or don’t start if GFR is 30-45, or planning metabolic surgery
Sulfonyureas
“ide”
Sulfonyureas SOA
Pancreas (requires functioning beta cells to work)
Sulfonyureas warnings
Hypoglycemia- Caution with elderly,
Don’t give if allergic to Sulfa
Don’t give in pregnancy
Low cost- Weight gain
TZDs
“Gliazones”
TZDs SOA
Nucleus
TZDs SE
Live toxicity, Risk of bone fx related to bone loss
TZDs warnings
No hypoglycemia
BLACK BOX- CHF- due to SE of fluid retention
DPP4
“Gliptins”
DPP4- SOA
Pancreas
DPP4 SE
pancreatitis- GI symptoms- Joint pains
DPP4 Warnings
High cost- neutral weight loss
NO hypoglycemia
Don’t use with GLP-1
GLP-1
“Tides”
GLP-1 SOA
Pancreas
GLP-1 MOA
Delays gastic emptying, improves postprandial glucose
GLP-1 SE
GI upset, inj site rx, pancreatitis
GLP-1 Warnings
High cost- weight lost
Dont use with DPP4
BLACK BOX- Thyroid CA
SGLT2
“Flozins”
SGLT2 SOA
Proximal Renal tubules- Kidneys
SGLT2 MOA
increase renal glucose excretions- Glycosuria
SGLT2 SE
GU infections, UTI, peeing more- Hypotension- increase risk for falls, increase risk for bone fx
Fournier’s
SGLT2 Warnings
High cost- Wight lost
No hypoglycemia
BLACK BOX- Risk of amputation
