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Pharmacology > DM 2 Oral Agents > Flashcards

DM 2 Oral Agents Flashcards

1
Q

Insulin secretagogues

A

Sulfonylureas

Meglitinides

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2
Q

MOA

Insulin secretagogues

A

Increases insulin secretion by inhibiting Beta-cell K-ATP channels

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3
Q

SE

Insulin secretagogues

A

Hypoglycemia

Weight gain

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4
Q

Biguanides

A

Metformin

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5
Q

MOA

Metformin

A

Stimulates AMPK (AMP activated kinase), decreasing glucose production and insulin resistance

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6
Q

SE

Metformin

A

Lactic acidosis

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7
Q

Thiazolidinediones

A

Pioglitazone

Rosiglitazone

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8
Q

MOA

Thiazolidinediones

A

Activates transcription regulator PPAR-gamma (peroxisome proliferator activated receptor), decreasing insulin resistance

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9
Q

SE

Thiazolidinediones

A

Fluid retention/HF

Weight gain

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10
Q

GLP-1 agonists

A

Exenatide

Liraglutide

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11
Q

MOA

GLP-1

A

Increases glucose-dependent insulin secretion, decreases glucagon secretion, delays gastric emptying

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12
Q

SE

GLP-1 agonists

A

Pancreatitis

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13
Q

DPP4 inhibitors

A

Sitagliptin

Saxagliptin

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14
Q

MOA

DPP4 inhibitors

A

Increases endogenous GLP-1 and GIP levels

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15
Q

SE

DPP4 inhibitors

A

Nasopharyngitis

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16
Q

Alpha-glucosidase inhibitor

A

Acarbose

Miglitol

17
Q

MOA

Alpha-glucosidase inhibitors

A

Reduces intestinal disaccharide absorption

18
Q

SE

Alpha-glucosidase inhibitors

A

Diarrhea

Flatulence

19
Q

SGLT2 inhibitors

A

Canagliflozin

Dapagliflozin

20
Q

MOA

SGLT2 inhibitors

A

Increases renal glucose excretion

21
Q

SE

SGLT2 inhibitors

A

UTIs

Hypotension

22
Q

GLP-1

A

Glucagon-like peptide 1

23
Q

GIP

A

Gastric inhibitory polypeptide

24
Q

SGLT2

A

Sodium glucose cotransporter 2

25
Q

DPP4

A

Dipeptidyl-peptidase 4

Pharmacology (2 decks)

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