DLE and SLE Flashcards
1
Q
What is discoid lupus?
A
Benign disorder generally seen in younger females
2
Q
How often does DLE become SLE?
A
In 5% of patients
3
Q
Features of discoid lupus?
A
- Erythematous raised rash, sometimes scaly
- May be photosensitive
- More common on face, neck, ears and scalp
- Lesions heal with atrophy, scarring (may cause scarring alopecia), and pigmentation
4
Q
What is the management of discoid lupus?
A
1) Topical steroids
2) Oral antimalarials (e.g. hydroxychloroquine)
- Avoid sun exposure
5
Q
What is systemic lupus erythematous?
A
A multisystem autoimmune disorder that is more common in women and people of afro-caribbean descent
6
Q
What antibodies are highly specific for SLE?
A
- Anti-dsDNA
- Anti-Smith’s
7
Q
What antibody is highly sensitive for SLE?
A
- ANA (90%)
- (useful rule out test)
8
Q
What antibody is generally used as a marker for drug induced lupus?
A
Anti-histone antibody
9
Q
What drugs commonly cause drug induced lupus?
A
- Procainamide
- Hydralazine
10
Q
What is the treatment for antiphospholipd syndrome?
A
- Primary thromboprophylaxis (no previous thrombosis): low dose aspirin
- Secondary thromboprophylaxis: lifelong warfarin +/- low dose aspirin if not effective
