DKA Flashcards
What is diabetic ketoacidosis?
A state of uncontrolled catabolism associated with insulin deficiency, primarily seen in type I diabetics
What is the pathogenesis behind diabetic ketoacidosis?
In the absence of insulin, hepatic glucose production accelerates, and peripheral uptake by tissues such as muscle is reduced. Rising glucose levels lead to an osmotic diuresis, loss of fluid and electrolytes, and dehydration. This results in plasma osmolality rising and renal perfusion falling. Vomiting leads to further loss of fluid and electrolytes.
In parallel, rapid lipolysis occurs, leading to elevated circulating FFA levels. These are broken down to fatty acyl-CoA within the liver cells, and are subsequently converted to ketone bodies within the mitochondria. Accumulation of ketone bodies produces a metabolic acidosis.
What factors contribute to the acidosis that develops in DKA?
- Accumulation of ketone bodies produces a metabolic acidosis.
- Progressive dehydration impairs renal excretion of hydrogen ions and ketones, aggravating the acidosis.
Why do individuals become dehydrated in DKA?
- Rising glucose levels lead to an osmotic diuresis, loss of fluid and electrolytes, and dehydration.
- Vomiting leads to further loss of fluid and electrolytes.
What are the most common circumstances which somebody develops a DKA?
- Previously undiagnosed diabetes
- Interruption of insulin therapy
- The stress of intercurrent illness
What are symptoms of someone with DKA?
- Polyuria
- Polydipsia
- Weight loss
- Weakness
- Nausea/vomiting
- Abdo pain
- Breathlessness
What are signs of DKA?
- Dry mucus membranes
- Sunken eyes
- Tachycardia
- Hypotension
- Ketotic breath
- Kussmaul resp.
- Altered mental state
- Hypothermia
Up to 5% can present in coma
Why do individuals with DKA have abdominal pain?
Acidosis causes ileus
What is Kussmaul’s breathing?
https://www.youtube.com/watch?v=TG0vpKae3Js
Also described as ‘air hunger’, Kussmaul’s breathing is typified by deep, rapid inspirations.
What is the mechanism behind kussmaul’s breathing?
Kussmaul’s breathing is an adaptive response to metabolic acidosis. By producing deep, rapid inspirations, anatomical dead space is minimised, allowing for more efficient ‘blowing off’ of carbon dioxide, thus decreasing acidosis and increasing pH.
Why do individuals with DKA get acetone breath?
Build up of ketones
What criteria are used for the diagnosis of DKA?
- Acidaemia
- Hyperglycaemia
- Ketonaemia/Ketronuria
What criteria are used to diagnosis acidaemia in DKA?
Venous pH < 7.3 mmol/L
OR
Bicarb < 15 mmol/L
What criteria would you use to diagnose Ketonaemia in somoene with DKA?
Blood ketones > 3 mmol/L
What criteria would you use to diagnose ketonuria in DKA?
2+ on dipstick
What criteria would you use to diagnose hyperglycaemia in someone with DKA?
Blood glucose > 11.0 mmol/L
How would immediately manage someone with DKA?
http://www.diabetesinscotland.org.uk/Publications/DKA%20Care%20Pathway%201%20v10.pdf
- ABCDE - get 2 large bore cannulas in
- Confirm diagnosis - H+ > 45 or HCO3 < 18 or pH < 7.3 on VBG
- Check - U&Es, lab Blood Glucose, urine or blood ketones
- Record time of arrival
What actions should you take within the first 60 minutes of admission in someone with DKA?
http://www.diabetesinscotland.org.uk/Publications/DKA%20Care%20Pathway%201%20v10.pdf
- Commence Fluids - 1L NaCl 0.9% over 1 hr within 30 mins of admission
- Commence soluble insulin - IV 6 units/hour within 30 mins of admission
- Record SEW45S/MEWS/SIRS score
How would you manage someone who has already had initial management between 1-4 hours?
http://www.diabetesinscotland.org.uk/Publications/DKA%20Care%20Pathway%201%20v10.pdf
Monitoring: SEWS, ECG, GCS, Lab Glucose, U&Es and HC
Stepwise fluid replacement
- Hour 2 - 1L/hour NaCl 0.9% + KCL
- Hour 3-4 - 500mls/hour NaCl 0.9% + KCL
Review K+ result - Administer KCL in 500ml NaCL based on K+
Check finger prick Blood Glucose hourly
If, when managing someone for DKA, their blood glucose falls below 14.0 mmol/L within the first 4 hours, how would you manage them?
http://www.diabetesinscotland.org.uk/Publications/DKA%20Care%20Pathway%201%20v10.pdf
Commence Glucose - 10% 500mls with 20 mmol KCl at 100ml/hour
Continue NaCl 0.9% at 400mls/hour + KCL until end of hour 4
Reduce insulin to 3 units/hour
Maintain Blood Glucose - >9 mmol/L and ≤14 mmol/L adjusting insulin rate as necessary
What insulin regime would you initially start someone on in DKA?
6 units/hour
What rate would you give NaCl at in someone with DKA in the first 2 hours?
1L per hour
What rate would you give someone fluids with DKA in hours 3 and 4 post admission?
Drop from 1L/hour to 500 mL/hour
When would you consider dropping the insulin dose someone is on from 6 units/hour to 3 units per hour?
When blood glucose <14 mmol/L
When would you consider restarting s/c insulin regimen?
When bicarbonate is normal and patient is eating and drinking
When would you stop I.V insulin and fluids in someone with DKA?
30 minutes after sc insulin regimen has begun
