dixon

Question 1

What is designed to provide continuous controlled releases of medication through a semi permeable membrane over a given period of time

Answer 1

transdermal patches

Question 2

Most common problem with patches

Answer 2

local irriation, erythema, and edema

Question 3

under the tongue?

Answer 3

sublingual

Question 4

projestins implanted under skin to release a drug over a prolonged duration? Ex birth control

Answer 4

implants

Question 5

the study of how a drug enters the body

Answer 5

pharmokinetics

Question 6

the process by which drug molecules are transferred from the site of administration to the circulating blood

Answer 6

absorption

Question 7

oral absoprtion requires

Answer 7

disruption, disintegration, dispersion, dissoloution

Question 8

initial disruption of a tablet coating or capsule shell is neccassary

Answer 8

disruption

Question 9

tablet or capsule contents must break apart

Answer 9

disintegration

Question 10

drug particles must be spread throughout the stomach or intestine

Answer 10

dispersion

Question 11

drugs must be dissolved in GI fluids

Answer 11

dissouloution

Question 12

the ___ ____ is form that exerts the effect

Answer 12

free drug

Question 13

All drugs in 2 forms in blood

Answer 13

bound to plasma proteins and as free drug

Question 14

is the amount of time that passes for the concentration of a drug to fall to 1/2 its blood level at anytime

Answer 14

half life t1/2)

Question 15

short action and quickily removed

Answer 15

short half life

Question 16

long acting and slowly removed

Answer 16

long half life

Question 17

for drugs to penetrate the CNS they must pass across _______

Answer 17

blood brain barrier

Question 18

passage across ______ involves simple diffusion in accordance to lipid solubility

Answer 18

placenta

Question 19

the bodys way of changing a drug so that it can be more easily excreted by the kidnys, most common site is the liver

Answer 19

metabolism (biotransformation)

Question 20

3 different mechanisms of metabolism

Answer 20

1. active to inactive
2. inactive to active
3. active to active

Question 21

an inactive compound may be formed from an active parent

most common

Answer 21

active to inactive

Question 22

inactive parent drug may be transformed into an active compound (termed prodrug)

Answer 22

inactive to active

Question 23

active parent drug may be converted to a second active compound which is than converted to inactive compound

Answer 23

active to actove