Diuretics DSA Flashcards
Riddle me four carbonic anhydrase inhibitors!
- Acetazolamide
- Brinzolamide (topical ophthalmic)
- Dorzolamide (topical ophthalmic)
- Methazolamide
Name for me four loop diuretics!
- Bumetanide
- Ethacrynic acid
- Furosemide (Lasix, generic)
- Torsemide
What are the two prototype Thiazide diuretics?
- Chlorthalidone
- Hydrochlorothiazide
Nearly all of the thiazide diuretics end in what?
What are the three that do not?
-thiazide
Indapamide
Metolozone
Chlorthalidone
What are the two categories of potassium sparing diuretics?
Mineralocorticoid antagonists (aldosterone antagonists)
Inhibitors of renal sodium channels
What are the two mineralocorticoid antagonists we were told about?
- Eplerenone
- Spironolactone (Aldactone, generic)
Name for me; two inhibitors of renal sodium channels.
- Amiloride
- Triamterene
Where do ADH antagonists act?
The collecting duct
Where do osmotic agents work?
The collecting duct, PCT and the thin descending limb
What diuretics work at the DCT?
Thiazides
What diuretics work at the thick ascending limb?
Loop
Where does acetalozamide work?
PCT
How does aldosterone increase water retention?
It increases the expression of both the ENAC and basolateral Na+/K+-atpase, leading to an increase in Na+ reabsorption and K+ secretion.
What is the most important site of K+ secretion by the kidney?
The collecting tubule
What are the effects of carbonic anhydrase inhibitors on the following…
Urinary electrolytes…
NaCL
NaHCO3
K+
And body pH
?
NaCl - increase
NaHCO3 - Significant increase
K+ - increase
Body pH = Drop
