Diuretics

Question 1

What is the mechanism of action of thiazide diuretics?

Answer 1

Inhibit Na+ reabsorption in the distal convoluted tubule

Question 2

Name three thiazides?

Answer 2

Bendroflumethiazide
Indapamide
Chlorthalidone

Question 3

What are thiazide diuretics used for?

Answer 3

HTN

Question 4

What is the mechanism of action of loop diuretics?

Answer 4

Inhibit the Na+/K+/2Cl- transporter in the thick ascending limb of loop of henle

Question 5

Name two loop diuretics

Answer 5

Feruosmide

Bumetanide (40X stronger than feruosmide)

Question 6

What conditions are loop diuretics used in? (3)

Answer 6

Used for oedema:

1. HF
2. Renal failure
3. Cirrhosis (2nd line)

Question 7

What is the mechanism of action of K+ sparing diuretics?

Answer 7

Aldosterone antagonist

Question 8

Name two K+ sparing diuretics?

Answer 8

Spironolactone

Eplerenone

Question 9

When are K+ sparing diuretics used? (2)

Answer 9

1. Cirrhosis (1st line)

2. Severe HF as an adjunct

Question 10

What is metolazone and when is it used?

Answer 10

Thiazide-like diuretic

Given in conjunction with ferusomide and causes massive diuresis