Diuretics

Question 1

Metolazone

Answer 1

Thiazide-like diuretic
Distal convoluted tubule
Inhibits sodium-chloride symporter

Question 2

Lasix

Answer 2

Loop of Henle

Inhibits Na-K-Cl pump, thereby causing increased excretion of water, sodium, chloride, magnesium and calcium

Question 3

Ethacryinic Acid

Answer 3

Ascending Loop of Henle and Distal renal tubule
(Not a sulfonamide like furosemide)
Inhibits reabsorption of sodium and water
Interferes with chloride-binding transport system

Risk of worse ototoxicity than lasix

Question 4

Aldactazide

Answer 4

Hydrochlorothiazide + spironolactone

Hydrochlorothiazide
Inhibits sodium reabsorption in the distal tubules, causing excretion of sodium, water, potassium and hydrogen ions

Spironolactone
Potassium sparing
Competes for aldosterone for receptor sites in distal renal tubules
Increases excretion of sodium chloride and water, conserves potassium and hydrogen