Diuretics Flashcards
How & where do loop diuretics work?
On the ascending limb of the loop of henle.
By inhibiting the Na/Cl/K channel in the TAL, meaning these are not reabsorbed into the circulation meaning less water is reabsorbed therefore more is excreted.
What are the main types of diuretic? (4)
- Loop
- Thiazides
- Potassium-sparing
- Carbonic anhydrase inhibitors
Name two examples of loop diuretics.
- Furosemide
- Bumetanide
How and where do thiazide diuretics work?
At the distal convoluted tubule, by inhibiting Na/Cl transporter.
Name two examples of thiazide diuretics.
- Bendroflumethiazide
- Indapamide
How do potassium-sparing diuretics work?
By antagonizing aldosterone receptors, less sodium (& therefore water) is reabsorbed, while potassium is retained.
(Aldosterone normally causes retention of sodium and water and excretion of potassium)
Name two examples of potassium-sparing diuretics.
- Spironolactone
- Epleronone
