Diuretics

Question 1

examples of loop diuretics?

Answer 1

furosemide, bumetanide, torasemide

Question 2

interaction to AVOID with loop diuretics?

Answer 2

NSAIDs ↓ diuretic action of furosemide (PG inhibition/ competition for OAT?)

Question 3

side effects of loop diuretics?

Answer 3

Hypotension (through hypovolaemia)
Hypokalaemia*
Metabolic alkalosis
Gout
Hearing loss (CN VIII damage?)

Question 4

examples of thiazide diuretics/

Answer 4

chlortalidone, indapamide*, metolazone, (bendroflumethiazide)

Question 5

side effects of thiazie diuretics?

Answer 5

Increased urinary frequency – is this a big problem?
Erectile dysfunction
Hypokalaemia
Impaired glucose tolerance (inhibits insulin secretion)

Question 6

examples of potassium sparing diuretics?

Answer 6

spironolactone, eplerenone

Question 7

side effects of potassium sparing diuretics?

Answer 7

Hyperkalaemia
GI upset
Gynaecomastia*
Menstrual disorders/ testicular atrophy

Question 8

what do K sparing diuretics interact with?

Answer 8

ACE INHIBITORS

(prils) and increase hypotensive effect