Diuresis

Question 1

Water diuresis

Answer 1

Excretion of large volume of water without loss of excess of solute.
Capacity of kidney tubule impaired.
ADH.
Diabetes insipidus

Demonstrated by drinking large amt of water, polyuria in 15-40 minutes

Question 2

Osmotic diuresis

Answer 2

Increased conc of osmotically active particles in tubular fluid increases excretion of water.
Diabetes mellitus.

Demonstrated by mannitol. Mannitol filtered in kidney but not reabsorbed so produces osmotic diuresis.

Question 3

Diuretics

Answer 3

Substances that promote diuresis.
To decrease ECF.
Loop, aldosterone, thiazide, carbonic anhydrase, xanthines, osmotically active substances, ethanol

Question 4

Loop diuretics

Answer 4

Furosemide

Inhibits Na+-K+-2Cl- cotransporter

Question 5

Aldosterone antagonists

Answer 5

Spironolactone

Inhibits action of aldosterone, and Na-K exchange causing natriuresis and diuresis.

Question 6

Thiazide

Answer 6

Chlorothiazide.

Distal tubule, inhibits nacl cotransporter