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MOD 4 - Pharmacokinetics > Distribution > Flashcards

Distribution Flashcards

1
Q

highly protein bounded drugs

A

diazepam, digoxin
indomethacin, tolbutamide
warfarin, midazolam

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2
Q

Vd: chloroquine

A

high

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3
Q

Vd: atropine

A

high

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4
Q

Vd: digoxin

A

high

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5
Q

Vd: fluoxetine

A

high

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6
Q

Vd: imipramine (TCAs)

A

high

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7
Q

Vd: beta blockers

A

high

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8
Q

Vd: chlorpropamide

A

low

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9
Q

Vd: furosemide

A

low

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10
Q

Vd: tolbutamide

A

low

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11
Q

Vd: warfarin

A

low

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12
Q

Vd: valproic acid

A

low

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13
Q

CYP: theophylline

A

CYP1A2

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14
Q

CYP: caffeine

A

CYP1A2

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15
Q

CYP: duloxetine

A

CYP1A2

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16
Q

CYP: melatonin

A

CYP1A2

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17
Q

CYP: clozapine

A

CYP1A2

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18
Q

CYP: ramosetron

A

CYP1A2

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19
Q

CYP: cyclophosphamide

A

CYP2B6

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20
Q

CYP: ifosfamide

A

CYP2B6

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21
Q

CYP: bupropion

A

CYP2B6

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22
Q

CYP: efavirenz

A

CYP2B6

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23
Q

CYP: repaglinide

A

CYP2C8

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24
Q

CYP: montelukast

A

CYP2C8

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25
Q

CYP: pioglitazone

A

CYP2C8

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26
Q

CYP: celecoxib

A

CYP2C9

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27
Q

CYP: phenytoin

A

CYP2C9

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28
Q

CYP: 2nd gen sulfonylureas

A

CYP2C9

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29
Q

CYP: tolbutamide

A

CYP2C9

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30
Q

CYP: S-warfarin

A

CYP2C9

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31
Q

CYP: omeprazole

A

CYP2C19

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32
Q

CYP: lansoprazole

A

CYP2C19

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33
Q

CYP: rabeprazole

A

CYP2C19

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34
Q

CYP: diazepam

A

CYP2C19
CYP3A4

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35
Q

CYP: voriconazole

A

CYP2C19

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36
Q

CYP: s-mephenytoin

A

CYP2C19

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37
Q

CYP: desipramine

A

CYP2D6

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38
Q

CYP: dextrometorphan

A

CYP2D6

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39
Q

CYP: eliglustat

A

CYP2D6

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40
Q

CYP: nebivolol

A

CYP2D6

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41
Q

CYP: nortriptyline

A

CYP2D6

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42
Q

CYP: perphenazine

A

CYP2D6

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43
Q

CYP: tolterodine

A

CYP2D6

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44
Q

CYP: venlafaxine

A

CYP2D6

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45
Q

CYP: amitriptyline

A

CYP2D6

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46
Q

CYP: encainide

A

CYP2D6

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47
Q

CYP: imipramine

48
Q

CYP: metoprolol

49
Q

CYP: propafenone

50
Q

CYP: propranolol

51
Q

CYP: tramadol

52
Q

CYP: trimipramine

53
Q

CYP: macrolides

54
Q

CYP: amiodarone

55
Q

CYP: cortisol

56
Q

CYP: grapefruit juice

57
Q

metabolic phase: chloramphenicol

A

Phase I: reduction
(nitro reduction)

58
Q

metabolic phase: naloxone

A

Phase I: reduction
(carbonyl reduction)

59
Q

metabolic phase: methadone

A

Phase I: reduction
(carbonyl reduction)

60
Q

metabolic phase: prontosil

A

Phase I: reduction
(azo reduction)

61
Q

metabolic phase: procaine

A

Phase I: hydrolysis
(esters)

62
Q

metabolic phase: aspirin

A

Phase I: hydrolysis
(esters)

63
Q

metabolic phase: enalapril

A

prodrug

Phase I: hydrolysis
(esters)

64
Q

metabolic phase: cocaine

A

metabolite: benzoic acid

Phase I: hydrolysis
(esters)

65
Q

metabolic phase: lidocaine

A

Phase I: hydrolysis
(amide)

66
Q

metabolic phase: indomethacin

A

Phase I: hydrolysis
(amide)

67
Q

metabolic phase: procainamide

A

Phase I: hydrolysis
(amide)

68
Q

metabolic phase: acetaminophen

A

Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase

69
Q

metabolic phase: diazepam

A

Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase

70
Q

metabolic phase: chloramphenicol

A

Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase

71
Q

metabolic phase: digoxin

A

Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase

72
Q

metabolic phase: morphine

A

Phase II: glucuronidation
enzyme: UDP-glucuronosyl transferase

73
Q

metabolic phase: isoniazid

A

Phase II: acetylation
enzyme: NAT1 and NAT2

74
Q

metabolic phase: hydralazine

A

Phase II: acetylation
enzyme: NAT1 and NAT2

75
Q

metabolic phase: procainamide

A

Phase II: acetylation
enzyme: NAT1 and NAT2

76
Q

metabolic phase: streptomycin

A

Phase II: acetylation
enzyme: NAT1 and NAT2

77
Q

metabolic phase: nicotinic acid

A

Phase II: glycine conjugation

78
Q

metabolic phase: ethacrynic acid

A

Phase II: glutathione conjugation

79
Q

metabolic phase: dopamine

A

Phase II: methylation

80
Q

metabolic phase: epinephrine

A

Phase II: glycine conjugation

81
Q

enzyme ind/inh:
broccoli

A

enzyme inducer (CYP1A2)

82
Q

enzyme ind/inh:
brussel sprouts

A

enzyme inducer (CYP1A2)

83
Q

enzyme ind/inh:
char-grilled meat

A

enzyme inducer (CYP1A2)

84
Q

enzyme ind/inh:
benzo-a-pyrene

A

enzyme inducer (CYP1A2)

85
Q

enzyme ind/inh:
ompeprazole

A

enzyme inducer (CYP1A2)

86
Q

enzyme ind/inh:
tobacco

A

enzyme inducer (CYP1A2)

87
Q

enzyme ind/inh:
rifampin

A

enzyme inducer (CYP2C9, 2C19, 2D6, 3A4)

88
Q

enzyme ind/inh:
dexamethasone

A

enzyme inducer (CYP2D6)

89
Q

enzyme ind/inh:
phenobarbital

A

enzyme inducer (CYP3A4)

90
Q

enzyme ind/inh:
st. john’s wort

A

enzyme inducer (CYP3A4)

91
Q

enzyme ind/inh:
carbamazepine

A

enzyme inducer (CYP3A4)

92
Q

enzyme ind/inh:
glucocorticoids

A

enzyme inducer (CYP3A4)

93
Q

enzyme ind/inh:
fluvoxamine

A

enzyme inhibitor (CYP1A2)

94
Q

enzyme ind/inh:
ciprofloxacin

A

enzyme inhibitor (CYP1A2)

95
Q

enzyme ind/inh:
fluconazole

A

enzyme inhibitor (CYP2C9)

96
Q

enzyme ind/inh:
amiodarone

A

enzyme inhibitor (CYP2C9)

97
Q

enzyme ind/inh:
PPI (except pantoprazole)

A

enzyme inhibitor (CYP2C19)

inhibits clopidogrel activation

98
Q

enzyme ind/inh:
fluoxetine

A

enzyme inhibitor (CYP2D6)

99
Q

enzyme ind/inh:
paroxetine

A

enzyme inhibitor (CYP2D6)

100
Q

enzyme ind/inh:
quinidine

A

enzyme inhibitor (CYP2D6)

101
Q

enzyme ind/inh:
duloxetine

A

enzyme inhibitor (CYP2D6)

102
Q

enzyme ind/inh:
terbinafine

A

enzyme inhibitor (CYP2D6)

103
Q

enzyme ind/inh:
indinavir

A

enzyme inhibitor (CYP3A4)

104
Q

enzyme ind/inh:
nelfinavir

A

enzyme inhibitor (CYP3A4)

105
Q

enzyme ind/inh:
ritonavir

A

enzyme inhibitor (CYP3A4)

106
Q

enzyme ind/inh:
clarithromycin

A

enzyme inhibitor (CYP3A4)

107
Q

enzyme ind/inh:
itraconazole

A

enzyme inhibitor (CYP3A4)

108
Q

enzyme ind/inh:
ketoconazole

A

enzyme inhibitor (CYP3A4)

109
Q

enzyme ind/inh:
nefazodone

A

enzyme inhibitor (CYP3A4)

110
Q

enzyme ind/inh:
saquinavir

A

enzyme inhibitor (CYP3A4)

111
Q

enzyme ind/inh:
telithromycin

A

enzyme inhibitor (CYP3A4)

112
Q

enzyme ind/inh:
aprepitant

A

enzyme inhibitor (CYP3A4)

113
Q

enzyme ind/inh:
erythromycin

A

enzyme inhibitor (CYP3A4)

114
Q

enzyme ind/inh:
fluconazole

A

enzyme inhibitor (CYP3A4)

115
Q

enzyme ind/inh:
grapefruit juice

A

enzyme inhibitor (CYP3A4)

MOD 4 - Pharmacokinetics (1 decks)

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