DISPERSE SYSTEMS Flashcards
Is a dispersion in which the dispersed phase is composed of small globules of a liquid distributed throughout a vehicle in which it is immiscible. They consist of globules that have diameters equal to or greater than those of the largest colloidal particles.
EMULSIONS
In emulsion terminology, the dispersed phase is called?
INTERNAL PHASE
In emulsion terminology, the dispersion medium is called?
EXTERNAL OR CONTINOUS PHASE
Emulsions with an oleaginous internal phase and an aqueous external phase are ________ emulsions.
OIL-IN-WATER (O/W)
Emulsions having an aqueous internal phase and an oleaginous external phase are termed as?
WATER-IN-OIL (W/O)
What is the third phase or substance in an emulsion system?
EMULSIFYING AGENT
It is necessary and is incorporated to prevent separation of the two phases?
EMULSIFYING AGENT
4 Phases:
DISPERSED PHASE
DISPERSION MEDIUM
AQUEOUS PHASE
NON-AQUEOUS PHASE
The purpose of the different phases:
INCREASE SOLUBILITY
INCREASE STABILITY
PROLONG DRUG ACTION
IMPROVE TASTE
IMPOROVE APPEARANCE
Oil is dispersed as droplets in an aqueous phase or medium?
OIL-IN-WATER EMULSION (O/W)
•Oral and external products
•Washable Products
OIL-IN-WATER EMULSION (O/W)
Water is dispersed as droplets in an oleaginous medium.
WATER-IN-OIL EMULSION (W/O)
It is used for external preparations when emollient, lubricating or protective properties are desired.
WATER-IN-OIL EMULSION (W/O)
O/W or W/O
MULTIPLE EMULSIONS
It is translucent or transparent
MACROEMULSIONS
It is used to prevent the coalescence and maintain the integrity of the individual droplets of dispersed liquid.
EMULSIFYING AGENT
Effectiveness depend on its:
•Chemical Structure
•Concentration
•Solubility
•pH
•Physical Properties
•Electrostatic Effect
EMULSIFYING AGENTS
2 types of emulsifying agents:
TRUE EMULSIFYING AGENTS
STABILIZERS
Are capable of forming and stabilizing emulsions by themselves?
TRUE EMULSIFYING AGENTS
Examples of True emulsifying agents:
ACACIA
GUM ARABIC
They do not form acceptable emulsions when used alone, but do not assist primary agents in stabilizing the product.
STABILIZERS
5 examples of stabilizers:
AGAR
GULAMAN
CHONDRUS
DEXTRIN
MALT EXTRACT
Natural emulsifying agents -ANIMAL SOURCE
CASEIN
CHOLESTEROL
EGGWOLK
GELATIN
WOOLFAT
Natural emulsifying agents- VEGETABLE SOURCE
AGAR
ACACIA
PECTIN
CHONDRUS
TRAGACANTH
Have high pH and therefore sensitive to the addition of acids and electrolytes.
ANIONIC SYNTHETIC AGENTS
Ex. Sodium Lauryl Sulfate
SULFURIC ACID ESTER
Ex. Dioctyl Sodium Sulfosuccinate
SULFONIC ACID DERIVATIVES
It is used for external use.
SOAPS
Are hydrophilic and form oil in water
ALKALI SOAPS
Are water insoluble and form water-in-oil
METALLIC SOAPS
Form oil in water
MONOVALENT SOAPS
Form water in oil
POLYVALENT SOAPS
Are used as surfaced-active agents in 1% concentration.
CATIONIC SYNTHETIC AGENTS
Are compatible with soaps
CATIONIC SYNTHETIC AGENTS
Ex. Benzalkonium Chloride
CATIONIC SYNTHEITC AGENTS