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Pathology: Diseases Of White Blood Cells, Lymph nodes, Spleen & Thymus > Disorders Of White Blood Cells > Flashcards

Disorders Of White Blood Cells Flashcards

1
Q

Types of White Blood Cell Disorder

A

Deficiency

Proliferative diseases

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2
Q

Types of proliferative diseases

A

Reactive

Neoplastic

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3
Q

Decreased number of circulating leukocytes

A

Leukopenia

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4
Q

Most common form of leukopenia

A

Neutropenia

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5
Q

Clinically significant neutropenia anf indicate the level

A

Agranulocytosis (<500/mm3)

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6
Q

Those with neutropenia are highly susceptible to what type of infection

A

Candida

Aspergillus

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7
Q

Most common cause of neutropenia

A

Drug toxicity

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8
Q

2 mechanisms of neutropenia

A

Inadequate or ineffective hematopoiesis

Inc destruction or sequestrations

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9
Q

Generally neutropenia with inadequate or ineffective granulopiesis are hypocrllular except

A

Megaloblastic anemias

Myelodysplastic syndrome

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10
Q

Congenital cause of neutropenia due to ineffective or inadequate granulopoiesis

A

Kostmann syndrome

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11
Q

Associated with suppression of hematopoietic stem cells

A

Aplastic anemia

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12
Q

Associated with suppression of committed granulocytic precursors

A

Drugs

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13
Q

Inc destruction mechanism of neutropenia are generally_____

A

Hypercellular

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14
Q

3 mechanisms of increased destruction it sequestration of neutropenia

A

Immunologic or inflammation
Splenomegaly
Inc peripheral utilization

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15
Q

Associated with immunologic or inflammatory mechanism

A

SLE and Drugs

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16
Q

Associated with splenomegaly neutropenia

A

Sequestration

17
Q

Associated with inc peripheral utilization

A

Overwhelming bact, fungal or rickettsial infections

18
Q

Mechanisms of leukocytosis

A

Inc prod of marrow
Inc release from marrow stores
Dec margination
Dec extravasation into tissues

19
Q

All are growth factor dependent mechanism of inc prod of marrow leukocytosis except

A

Myeloproliferative disroders (chronic myeloid leukemia)

20
Q

Growth factor dependent

A

Chronic infection or inflammation

Paraneoplastic

21
Q

Associated with paraneoplastic mechanism

A

Hodgkin’s disease

22
Q

Associated with inc release from marrow stores

A

Endotoxemia
Infection
Hypoxi

23
Q

Associated with dec margination leukocytosis

A

Exercise

Catecholamines

24
Q

Associated with dec extravasation into tissues

A

Gluccocorticoids

Pathology: Diseases Of White Blood Cells, Lymph nodes, Spleen & Thymus (1 decks)

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