Disorders of salt and water Flashcards

1
Q

hypernatremia

A

water content of body fluid is deficient in relation to sodium content (>145)

either too much salt or not enough water

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2
Q

what does hypernatremia usually result from?

A

inadequate fluid intake or excess water loss.

causes:
deficit of thirst
hypotonic fluid loss
urinary loss
GI loss
insensible loss
burns
diuretic theraphy
osmotic diureses (hyperglycemia or mannitol administration)
sodium excess
DI
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3
Q

what population does Hypernatremia usually presnet?

A

elderly and infants w/ D

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4
Q

what are clinical features of hypernatremia?

A

neruological manifestations that result from alterations in the brain water content and include thirst, restlessness, irritability, disorientation, lethargy, delierium, convulsion, coma

-possible brain cell shrinkage that can cause damage to the supporting vasculature

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5
Q

what are some signs of hyper N

A

dry mouth, dry mucus membranes, lack of tears and decreased slivation, flushed skin, tachycardia, hypotension, fever, oliguria, anuria, hyperventilation, lethargy, hyperreflexia

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6
Q

what can you look at in children to test for dehydration?

A

clinical dehydration scale

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7
Q

diagnostic studies of hyperN

A

serum >145

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8
Q

when would urine sodium be decreased?

A

if hyper N is due to extrarenal losses

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9
Q

when is urine sodium increased?

A

if hyper Na is due to renal loss or sodium excess

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10
Q

when is urine dilute in hyper Na?

A

DI

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11
Q

tx of hyper na

A

inpatient

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12
Q

what is the medication route for hyperNa

A

free water (po preferred, but can do IV or SQ) as a %5 dextrose solution in water or saline

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13
Q

what should be treated first in hyperNa?

A

hypovolemia- w/ isotonic saline or lactated ringers

then hyper na

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14
Q

when should dialysis be implemened?

A

if sodium is greater than 200

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15
Q

what must you be cautious of when treating hyperNa?

A

pulmonary or cerebral edema!! especially in pts w/ DM

-don’t rapidly correct

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16
Q

hyponatremia

A

plasma sodium concentration of less than 135 , but sx may not ocur until less than125

17
Q

what isthe most common electrolyte disorder seen in general hospital populatio?

A

hypoNa and its caused by hypotonic fluid administration

18
Q

what can cuase hyponatremia w/ hypervolemia

A

CHF, nephrotic syndrome, renal filure, and hepatic cirrhosis

19
Q

what can cause hyponatremia w/ euvolema

A

hypothyroidism, glucocorticold excess, SIADH

20
Q

what is SIADH defined by?

A

hypotonic hypoNa, urine osmolality of greater than 100, normal cardiac, hepatic, thyroid, adrneal and renal fx, and the absence of extracellular fluid volume deficit

urine sodium is > 40

21
Q

hypoNa w. Hypovolema?

A

renal or nonrenal sodium loss

22
Q

what are clinical features of hyponatermia

A

lethargy, disorientation musce crmaps, anorexia, hicups, N, V, seizures

23
Q

what are signs of hypona?

A

wekaness, agitation, hyporeflexia, orhtostatic hypotension, cheyne-strokes, delirium, coma, or stupor

24
Q

what are cheyne-strokes?

A

characterized by progressively deeper, and sometimes faster, breathing followed by a gradual decrease that results in a temporary stop in breathing called an apnea. The pattern repeats, with each cycle usually taking 30 seconds to 2 minutes.[1] It is an oscillation of ventilation between apnea and hyperpnea with a crescendo-diminuendo pattern, and is associated with changing serum partial pressures of oxygen and carbon dioxide

25
Q

what would lab studies would you do if expected hypoNa?

A
  • serum sodium less than 135
  • plasma osmolality is usually decreased (except in cases of fluid redistribution due to hyperlycemia or proteinemia
  • urine sodium is either increased or decreased depending on cause
26
Q

what diagnositic imagigin would you get is suspected SIADH?

A

CT- rule out CNS disorder

CXR- r/o lung pathology

27
Q

tx of hypoNa?

A

inpt basis- iff less than 125,

28
Q

what is the tx if hypovolemic hyponatremia?

A

isotonic saline

29
Q

what can be used to tx sx hypona w/ sodium less than 120?

A

hypertonic saine

30
Q

what ares some complications of rapid correction of hypona?

A

central pontine myelinolysis that can lead to neurological damage

31
Q

what can be used when chronic hypona is unrepsondive to fluid restriction

A

demeclocycline- used to induce nephrogenic DI, but may cause nephrotoxicity in pts w/ chirrhosis

32
Q

what drug can be used in euvolemic or hypervolemic hyponatremia?

A

vasopressin antagonist (conivaptan)

33
Q

what are the ADR of Vaptans?

A

fever, hypokalemia, injury to IV ste, orhtostatic hyopthension

rare: anemia, a fib, confusion, cconstipation, dehydration, D, dry oth

34
Q

what is SIADH?

A

syndrome of inappropriate ADH secretion- opposite of DI; too much ADH being made

  • *normovolemic hypoNa
  • pple resrb water (the quaporin effect) more than is homeostatie
35
Q

what are sx of SIADH?

A

HTN and decreased serum sodium

36
Q

tx of SIADH

A

can be drug induced, restrict fluid, demeclocycline, vasporessing resceptor antatgoinst

37
Q

what drugs can cause SIADH?

A

nicotine, phenothiazines, tricyclins (stimulate release of ADH)

-desmopressin, oxytocin, protatglandin- increase the renal action of ADH

  • chlorpropamide,
  • carbamazepine
  • cyclophosphamide
  • vincristine
  • omeprazole
  • ecstasy