Disorders of haemostasis

Question 1

what are abnormal disorders of haemostasis?

Answer 1

thrombosis, embolism
formation of blood clot
obstructing blood flow

Question 2

what are arterial disorders of haemostasis?

Answer 2

white clot: (lack of blood flow)
CVA
MI: antiplatelet & thrombolysis

Question 3

what are venous disorders of haemostasis?

Answer 3

red clot: (deoxygenated blood)
DVT
PE: anti-coagulation

Question 4

what are other uses of antiplatelets & anticoagulants?

Answer 4

patient in pro-thrombotic state

primary prevention

Question 5

what are the components fo virchow’s triad?

Answer 5

blood component: hypercoagulability (genetic VS enquired)
vessel wall: endothelial damage
blood flow: stasis

Question 6

what are genetic causes of hypercoagulable state?

Answer 6

protein C & S deficiency

factor V Leiden: mutated factor V (causing hypercoagulabe)

Question 7

what are enquired hypercoagulable state causes?

Answer 7

antiphospholipid syndrome
OCP
smoking
malignancy
prosthetic heart valve

Question 8

what are arterial causes of endothelial damage?

Answer 8

atheroma (MI, CVA)
hypertension
Toxin: cigarettes, homocysteine

Question 9

what are arterial cause of stasis of blood flow?

Answer 9

cardiac abnormality (arterial)
AF, congestive HF (CCF), mitral valve disease (left, CO), post  MI (ectopic foci)

Question 10

what are venous cause of stasis of blood flow?

Answer 10

immobility & thrombosis:

1. ill health
2. post-op (immobility)
3. economical class