Disorders of Coagulation Flashcards
prolongation of both PT and aPTT suggests which deficiency of coagulation factors?
prolongation of both PT and aPTT suggests deficiency of FV, FX, FII, or fibrinogen abnormalities
development of antibodies to coagulation plasma proteins occurs in which circumstances?
exposure to the missing protein; underlying autoimmune or neoplastic disease or idiopathically
% of cases that are hemophilia A?
hemophilia A represents 80% of all
cases
Family history of the disease is absent in % of cases?
Family history of
the disease is absent in ~30% of cases
what are levels of factors necessary in hemophilia?
15–25% for 2 or 3 days for severe hemarthroses; Large hematomas levels of 50%; oropharyngeal spaces, CNS, and the retroperitoneum 50–100% for 7–10 days; Prophylactic replacement for surgery 100% for a period of 7–10 days
% of patients older than 20 years of age who are HCV antibody positive?
> 80% of patients older than 20 years of age are HCV antibody positive as of 2006
Mortality in CID?
The mortality ranges from 30 to >80% depending on the underlying disease, the severity of the DIC, and the age of the patient.
Which is the most sensitive test for DIC?
the most sensitive test for DIC is the FDP level
In which circumstances it is effective to use heparin in CID?
low-grade DIC associated with solid tumor, acute promyelocytic leukemia, or in a setting with recognized thrombosis. Heparin is also indicated for the treatment of purpura fulminans during the surgical resection of giant hemangiomas and during removal of a dead fetus.
Does heparin improve survival in CID patients?
To date, the use of heparin in patients with severe DIC has no proven survival benefit.
Which is the most common factor in aquired Inhibitors?
FVIII is the most common target of antibody formation.
