Disorders Flashcards
1
Q
Explain HIT?
A
Heparin Induced Thrombocytopenia. Heparin binds the inhibitor of antithrombin causing increased AT activity. This can lead to platelet destruction where the fragments cause thrombosis of the remaining platelets
2
Q
What is DIC?
A
pathological activation of the coagulation cascade
3
Q
What are the lab findings of DIC?
A
decreased platelets increased PT/ PTT decreased fibrinogen microangiopathic hemolytic anemia elevated fibrin split products (D dimer)
4
Q
What causes DIC?
A
sepsis obstetric complication adenocarcinoma APL (acute promyelotic anemia) Rattlesnake venom
5
Q
What converts plasmniogen to plasmin in fibrinolysis?
A
tPA, tissue plasminogen activator
6
Q
What does plasmin cleave?
A
fibrin, fibrinogen, coag factors
7
Q
What cleaves plasmin?
A
alpha2 antiplasmin
8
Q
what are the lab findings of a fibrinolysis disorder?
A
increased PT/PTT (destroyed factors)
increased bleeding time
increased d dimer
9
Q
what is aminocaproic acid used to treat?
A
Fibrinolysis disorders. blocks activation of plasminogen
