Diseases of the Stomach and Duodenum Flashcards
Describe the two types of hiatal hernias 1 and 2-4
1: Displacement of the gastroesophageal junction above the diaphragm. Fundus below
2-4: True hernia with a hernia sac. *Fundus through defect in the phrenoesophageal membrane
How does a Hiatal hernia present? How do we diagnose? What is the treatment?
Present: GERD symptoms
Diagnosis: Barium Swallow
Tx: Small –> Gerd mgmt
Large –> Surgical repair
Muscosal biopsy is necessary to differentiate what?
Gastritis and gastropathy
What are the most common etiologies of Erosive and hemorrhagic gastropathy?
*NSAID
*Alcohol
Physical stress
Portal hypertension
What are the general symptoms and signs of erosive and hemorrhagic gastropathy?
Anorexia, Epigastric pain, *could be asymptomatic
Can have Upper GI bleed.
Gastroprotective prostaglandings are derived from what? What are the functions of Gastric prostaglandins?
COX-1
- Release more bicarb and mucus ( dec perm and dec acid back-diffusion)
- Vasodilators (increase res to injury)
Describe S/Sx of NSAID gastropathy, Tx, and further evaluation
S/Sx - mainly Dyspepsia
Tx - discontinue NSAID or reduce to lowest dose. Switch to COX 2.
- If NSAID must be continued, take with milk of food and **Add daily PPI
If stuff doesnt resolve or + alarm signs, Upper endoscopy
Ethanol has direct toxic effect on gastric mucosa. Also, it impairs ______ leading to ______ gastric emptying.
Gastric motility
delayed
**Leads to prolonged contact w/ gastric mucosa –> injury
How does Alcoholic Gastropathy present? How do we treat?
S/Sx: Dyspepsia, nausea, vomit, minor hematemesis
Tx= no alcohol. H2 or PPI for 2-4 weeks.
Stress gastropathy is often seen in ________ patients. Highest risk of signifigant bleeding is associated with what 2 conditions?
Critically ill
Coagulopathy, Resp failure w/ mech vent
Critically ill patients should prophylactically recieve what medication for stress gastropathy? How do you treat an active bleed?
IV PPI
IV PPI
Portal hypertensive gastropathy leads to congestion which increases gastric blood flow pathalogically. How do we tx this?
Beta blocker for portal hyper
H. Pylori is the most common cause of what?
Peptic ulcer disease
Who gets tested for H Pylori (generally)
Dyspeptic pts
Chronic GERD patients
PUD patients
Pts should discontinue what for how long prior to H pylori testing?
Anti-secretory therapy x 2 weeks
Look at “Other types of gastritis”
Pernicious, infectious, eosinophil, menetrier
Pernicious - b12
Infectious - infectious usually immunocomp
Eosinophil - rare, post eat vomit
Menetrier - ideopathic hypertrophic
Define peptic ulcer disease. Where is it most common? What age groups alter this?
A break in the gastric or duodenal mucosa due to impaired mucosal defense mechanisms.
5x more common in the **Duodenum
Young = duodenum 55+ = gastric