Diseases of the External Eye Flashcards
3 Parts of Conjuctiva
Palpebral
Forniceal
Bulbar
Lines the anterior sclera
Bulbar conjunctiva
Includes the caruncle and plica semilunaris at the medial canthus
Bulbar Conjunctiva
How many layers of epithelial cells are found in conjunctiva
2-5 layers of stratified columnar epithelial cells
What kind of epithelium lines the conjunctiva?
Stratified Columnar
Superficial or Basal Epithelium of Conjunctiva?
Secretes goblet cells and makes conjunctiva moist
Supeficial
Superficial or Basal Epithelium of Conjunctiva?
Contains Melanocytes and Lymphocytes
Basal
2 Parts of Conjunctival stroma
Superficial adenoid and deep or fibrous
when is superficial adenoid begins to form?
2nd to 3rd month of life
Conjunctival stroma that contains lymphoid tissue and follicle like structures
Superficial adenoid conjunctival stroma
Connective tissue loosely bound to tarsus
Deep or Fibrous Stroma conjunctival stroma
Accessory lacrimal glands found in the deep/ fibrous stroma of conjunctiva
Krause and Wolfring
Signs of Conjunctival Pathology
Vascular changes Hyperemia Dilated Vessels Swelling/Edema/Chemosis Discolorations Discharge Masses
Icteria affects the sclera or conjunctiva?
Conjunctiva
Symptoms of Conjunctival Pathology
Discomfort Foreign body sensation Itching Burning sensation Tearing
Categorize Conjunctival Injection:
Conjunctivitis
Conjunctival
Categorize Conjunctival Injection:
Corneal Ulceration
Mixed
Categorize Conjunctival Injection:
Rosacea
Pericorneal
Categorize Conjunctival Injection:
Foreign body near the limbus
Pericorneal
Categorize Conjunctival Injection:
Herpetic keratitis
Pericorneal
Categorize Conjunctival Injection:
Episcleritis
Ciliary
Categorize Conjunctival Injection:
Scleritis
Ciliary
Categorize Conjunctival Injection:
Disciform Keratitis
Ciliary
Categorize Conjunctival Injection:
Iritis
Ciliary
Categorize Conjunctival Injection:
Cyclitis
Ciliary
Congestion at the periphery
The color is more redish
Conjunctival Congestion
Congestion is more at the perilimbar area (beside the limbus)
Ciliary Congestion
What vessels are involved in Ciliary congestion?
Anterior (Deep) Conjunctival Vessels
Congestion that is more localized
Pericorneal Congestion
How to differentiate Conjunctival from Ciliary Congestion using ocular decongestant?
Ocular decongestant is only efficient in conjunctival congestion
2 major reactions that occur in conjunctiva
Follicular and Papillary Reaction
But mixed type can occur
What vessels are involved in Conjunctival congestion?
Posterior (Superficial) Conjunctival Vessels
What conjunctival reaction will have lymphoid germinal centers?
Follicular Reaction
What conjunctival reaction will have smooth nodules?
Follicular reaction
What conjunctival reaction will have avascular apices surrounded by fine vessels at the base?
Follicular reaction
Pathogens involved in Follicular reaction
Adenovirus Enterovirus Molluscum contagiosum HSV Chlamydia Drug toxicity
What conjunctival reaction will have non specific response?
Papillary reaction
Papillary reaction is seen on?
Upper Tarsal Conjunctiva
What pattern is seen in Papillary reaction?
Fine mosaic pattern of dilated telangiectatic vessels
In papillary reaction, each papilla has a central fibrovascular core that gives rise to a vessel branching out in a _____ pattern
Spoke-like
3 Major types of conjunctivitis
Bacterial
Viral
Allergic
Mainstay of treatment in Viral Conjunctivitis
Supportive Treatment
Steroids
Frequent handwashing
Pathogen involved in Epidemic Keratoconjunctivitis
Adenovirus 8, 11, 19
Clue: 8+ 11 is 19
Pathogen involved in Pharyngoconjunctival fever
Adenovirus 3, 4, 7
Onset of Viral Conjunctivitis
Acute
Onset of Bacterial Conjunctivitis
Acute
Onset of Gonococcal / Newborn Conjunctivitis
Hyperacute
Manifestation of Viral Conjunctivitis
Watery Discharge
Pre-auricular lymphadenopathy
Mixed papillary- follicular
Others: Photophobia Foreign body sensation Chemosis Subconjunctival hemorrhage Pseudo membrane or true membrane
Usual complaint in Bacterial conjunctivitis
Cant open eyes because of matting
Manifestation of Bacterial conjunctivitis
Purulent or mucopurulent discharge
Photophobia
Foreign body sensation
Matting of eyelashes
Most common etiology of Bacterial conjunctivitis
Staphylococcus Streptococcus Chlamydia Haemophilus Neisseria gonorrhoeae
Mainstay of treatment in Bacteria Conjunctivitis
Antibiotics
Description of discharge in gonococcal conjunctivitis
Cheesy
Mode of transmission of gonococcal conjunctivitis
Genital-Hand-Ocular transmission
example: Myth of treating eyes with urine
Involvement of cornea in Gonococcal conjunctivitis can progress to?
Melting and perforation of intact epithelium
Classic cause of neonatal conjunctivitis
Perinatal transmission
Gram stain result of Gonococcal conjunctivitis
Presence of Gram negative intracellular diplococci
Coffee/ kidney shaped diplococci
Antibiotic used in Gonococcal conjunctivitis
Ceftriaxone
Adults: 500- 1000 mg
Children: 250 mg
Concurrent infection with gonococcal conjunctivitis
Chlamydia
Antibiotic used in gonococcal conjunctivitis plus chlamydia
Azithromycin
Other name for Chlamydial conjunctivitis
Inclusion Conjunctivitis
Etiology of Chlamydial Conjunctivitis
Chlamydia trachomatis D to K
Conjunctival response in Chlamydial Conjunctivitis
Follicular response with non tender lymphadenopathy
Gram stain result of Chlamydial conjunctivitis
Presence of inclusion bodies
Sequelae of Chlamydial conjunctivitis
Trachoma
Other diseases in concurrent with Chlamydial conjunctivitis
Urethritis
Cervicitis
Result of neovascularization in trachoma
Pannus
Evidence of scarring on the conjunctiva in Trachoma
Arlt’s line
Basedown configuation of keratic precipitates on the corneal epithelium
Arlt’s triangle
Duration of Viral conjunctivitis
3 days to 1 week
Arlt’s Trangle is seen in?
Uveitis
Elevated lesion found under the lids causing constant pressure with the cornea and limbus can cause?
Herbert’s pit
In acute setting, follicular conjunctivitis and epithelial keratitis can be seen in?
Trachoma
Depression or atrophic follicles at the corneal limbus representing areas that are slightly thinned out
Herbert’s pit
True of False
Herbert’s pit can lead to secondary bacterial infection
True
What type of hypersensitivity is Allergic Conjunctivitis?
Type 1
Hallmark of Allergic Conjunctivitis
Itching
What type of immunoglobulin is present in allergic Conjunctivitis?
IgE
What type of allergen causes allergic Conjunctivitis?
Airborne allergens
Temporal profile of allergic Conjunctivitis
Episodic and Short lived
Presence of diffuse papillary hypertrophy with giant cobblestone papillae
Vernal keratoconjunctivitis
treatment of vernal keratoconjunctivitis
Topical antihistamines
Mast cell stabilizers
Steroids
Signs and symptoms of vernal keratoconjunctivitis
Intense itching Blepharospasms Photophobia Blurred vision Copius mucoid discharge
Epidemiology of Vernal Keratoconjunctivitis
Young males
4-16 yo
History of Atopy
Type of Seasonal, Reccuring, Bilateral Allergic Conjunctivitis
Vernal Keratoconjunctivitis
Pathognomonic to Limbal Vernal Keratoconjunctivitis
Horner Trantas Dots
Limbus is thickened and gelatinous with scattered opalescent mounds and vascular injection
Limbal Vernal Keratoconjunctivitis
Oval or shield-shaped sterile epithelial ulcers with underlying stromal opacification
Shield ulcer
Chronic Inflammation of the conjunctiva with prominent papillary hypertrophy
Giant Papillary Conjunctivitis
Commonly associated with contact lens use (protein debris and chemical cleansers)
Giant Papillary Conjunctivitis
Seen in Ocular prosthesis, Loose Nylon Suture sand Filtering blebs
Giant Papillary Conjunctivitis
Rupture of conjunctival blood vessel due to trauma, valsalva, blood dyscrasia or infection
Or pooling of blood in the subconjunctival space
Subconjunctival Hemorrhage
True or False
Subconjunctival hemorrhage will cause blurring of vision
False
Treatment of Subconjunctival Hemorrhage
Observe (7-14 days) Vitamin C Ocular Lubricants Cold compress (1st 12 to 24 hrs) Warm compress succeeding hours
Congenital hamartomas that consists of nests of modified melanocytes
Conjunctival Nevus
Modified melanocytes also know as?
Nevus cells
Types of Conjunctival Nevus
Junctional
Compound
Subepithelial
True or False
Conjunctival Nevus are usually malignant
False
Represent trapped foreign body such as dust in the conjunctival epithelium
Conjunctival Concretions
Symptom of Conjunctival Concretions
Foreign body sensation
Elevated, fleshy conjunctival masses located in the inter-palpebral region, most commonly on the nasal side
Pinguecula
Worsened Pinguecula can lead to?
Pterygium
Usual color of Pinguecula
Yellow or light brown
Associated conditions with Pinguecula
Chronic Actinic exposure
Repeated Trauma
Dry windy condition
Triangular wing-shaped fleshy fibrovascular tissue encroaching upon the cornea occurring at the nasal side but can also occur in both nasal and temporal
Pterygium (Pugita)
Pterygium that meets at the center is called
Kissing Pterygium
Aka Surfer’s Disease
Pterygium
Risk Factors for Pterygium
UV light Wind & dust Farmers Fishermen People exposed to sunlight
Indications for surgery in Pterygium
Reduced vision due to invasion of visual axis
Irregular astigmatism
Significant ocular irritation
True or False
Pyrogenic represents granulomatous inflammation
False
Reactive proliferation of vascular endothelial cells and granulation tissue
Pyrogenic Granuloma