Diseases of Nervous Tissue

Question 1

Parkinsons Disease

Answer 1

• Neurological disorder
• Loss of Dopamine secreting cells in substantia nigra + basal ganglia
• Increase in number of glial cells
• Treatment – Primarily Symptomatic-L-Dopa primary agent

Question 2

Myasthenia Gravis

Answer 2

• disease affecting Neuromuscular junction
• impaired transmission of nerve impulses
• autoimmune attack on acetylcholine receptors

Question 3

Guillain Barre Syndrome

Answer 3

• demyelinating disease of PNS
  
  • common, life threatning
  • Nerve fibers = large accumulation of lymphocytes, macrophages and **plasma cells **
  • Loss of muscle co–ordination & cutaneous sensation

Question 4

Multiple sclerosis

Answer 4

• demyelinating disease of CNS
• preferential damage to myelin = detach from axon + destroyed
• destruction of oligodendrocytes
• symptoms = area of CNS where myelin is destroyed

Question 5

Hirschsprung Disease

(congenital mega colon)

Answer 5

• Mutations in one to four different gene
• Arrest in migration of neural crest cells to one segment of distal colon
• Absence of enteric nervous system