Disease of Immunity

Question 1

Autoimmune Disease manifesting Ab’s against

M Protein cross react with cardiac tissues

Answer 1

Acute Rheumatic Fever

Question 2

Autoimmune Disease manifesting Ab’s against

Basement Membrane of Kidney and Lung

Answer 2

Good Pasture’s syndrome

Question 3

Autoimmune Disease manifesting Ab’s against

TSH Receptor

Answer 3

Grave’s Disease

Question 4

Autoimmune Disease manifesting Ab’s against

Nicotinic Ach Receptor

Answer 4

Myasthenia Gravis

Question 5

SLE AutoAb

Answer 5

ANA, Anti-dsDNA

Question 6

Drug-induced Lupus AutoAb

Answer 6

Anti-Histone

Question 7

Mixed Connective Tissue Disease AutoAb

Answer 7

Anti-RNP(ribonucleoprotein)

Question 8

CREST Syndrome AutoAb

Answer 8

Anti-Centromere

Question 9

CREST Syndrome

Answer 9

Calcinosis
Raynaud's Phen
Esophageal Dysmotility
Sclerodactyly
Telangiectasia

Question 10

Diffuse Scleroderma AutoAb

Answer 10

Anti-Scl 70 (Anti topoisomerase)

Question 11

Sjogren Sydrome AutoAb

Answer 11

Anti-SSA

Question 12

Primary Biliary Cirrhosis AutoAb

Answer 12

Anti-mitochondrial

Question 13

Autoimmune Hepatitis AutoAb

Answer 13

Anti-smooth muscle

Question 14

Kawasaki Disease AutoAb

Answer 14

Anti-Endothelial

Question 15

Wegener Granulomatosis AutoAb

Answer 15

Anti-Proteinase 3 (C-ANCA)

Question 16

Microscopic Polyangitis AutoAb

Answer 16

Anti-Myeloperoxidase (P-ANCA)

Question 17

Chrug Strauss AutoAb

Answer 17

Anti-Myeloperoxidase (P-ANCA)

Question 18

Hashimoto’s AutoAb

Answer 18

Anti-Thyroglobulin

Question 19

Microorganism implicated with GBS

Answer 19

Campylobacter Jejuni

Question 20

Demyelinating Neuropathy manifesting with

Ascending Neuromuscular Paralysis

Answer 20

GBS

Question 21

Management of Multiple Sclerosis

Answer 21

Anti-MBP Natalizumab

Question 22

Most Common cause of hypothyroidism in iodine sufficient areas

Answer 22

Hashimoto’s Thyroiditis

Question 23

___a Disease where it manifest when Gliandin stimulates cytotoxic attack on enterocyte causing ___

Answer 23

Celia Disease

Villous Atrophy

Question 24

SLE Criteria for diagnosis:

__ / 11

Answer 24

Serositis (Pericarditis, Pleuritis)
Oral ulcers
Arthiritis (Non erosive)
Photosensitivity

Blood dso (Hemolytic Anemia, Leukopenia, Lymphopenia, Thrombocytopenia)
Renal (GN Diffuse Proliferative)
ANA (+)
Immunologic (Anti dsDNA, Anti-Sm)
Neurologic (Sz, Psychosis)

Malar Rash
Discoid Rash

4/11

Question 25

Chronic disease characterized by Dry Eyes, Dry mouth, Arthritis

Answer 25

Sjogren Syndrome

Question 26

Triad of Sjogren Syndrome

Answer 26

Sicca Keratoconjunctivitis Xerostomia Arthritis

Question 27

Immunologic Destruction of Lacrimal and Salivary Glands

Answer 27

Sjogren syndrome

Question 28

Drug used to treat Sjogren Syn

Answer 28

Corticosteroids Artificial Tears Pilocarpine

Question 29

Chronic Inflammation Small Blood vessels interstitial and perivascular fibrosis

Answer 29

Systemic Sclerosis

Question 30

4 types of Graft

Answer 30

Autograft - Self Allograft - same Spp Syngeneic Graft/Isograft - twin-twin Xenograft - different species

Question 31

(3) Types of Rejection of Tissue Transplant

Answer 31

``` Hyperacute Rejection Acute Rejection AC AH Chronic Rejection ```

Question 32

Most Common type of transplant Rejection

Answer 32

Acute Rejection

Question 33

Primary Bcell Immunodef

Answer 33

Bruton's Agammaglobunemia Selective IgA Def Common Variable Immunodeficiency

Question 34

Primary T Cell immunodef

Answer 34

Di George Syndrome | Chronic Mucocutaneous Candidiasis

Question 35

Di George Syndrome (CATCH 22)

Answer 35

``` Cardiac defect (TOF) Abnormal facies Thymic aplasia Cleft palate Hypocalcemia 22q11.2 chr. deletion ```

Question 36

Combined B - T cell Dso

Answer 36

SCID Wiskott Aldrich Syndrome Ataxia Telangiectasia

Question 37

Virtual Absence of Bcells due to Tyr Kinase Mutation

Answer 37

Bruton's Agammagobinemia/ X-linked hypogammaglobinemia

Question 38

Failure of isotype switching

Answer 38

Selective IgA def

Question 39

Defect in Bcell maturation to plasma cell

Answer 39

Common variable immunodef

Question 40

profound deficit in t cells; failure of development of thymus and parathyroid glands

Answer 40

DiGeorge syn

Question 41

mutation in gene encoding for common gamma chain/IL 2 receptor gamma

Answer 41

SCID

Question 42

lack of NADPH oxidase failure of oxidative burst

Answer 42

CGD

Question 43

failure of phagolysosomal fusion faulty microtubules impair neutrophil chemotaxis

Answer 43

chediak higashi syndrome

Question 44

defective adhesion LFA1 on the surface of the phagocyte

Answer 44

Leukocyte adhesion defeciency

Question 45

deficiancy of c1 inhibitor leads to increase c3a, c5a

Answer 45

hereditary angioedema

Question 46

most common complement defect

Answer 46

C2 deficiency