Diphenhydramin Benadryl

Question 0

Mechanism of action

Answer 0

Nonspecific competitive H1/h2 antagonist-blocks histamine release, suppresses central cholinergic activity and inhibits reuptake and storage of dopamine, leading to prolonged action of dopamine and reduction of bronchoconstriction, vasodilation, increased vascular permeability.

Question 1

Drug classification

Answer 1

Antihistamine

Question 2

Onset

Answer 2

10 - 15 min IV, 15-30min PO

Question 3

Peak

Answer 3

1-4 hours

Question 4

Duration

Answer 4

6-8 hours

Question 5

Half life

Answer 5

1-4 hours

Question 6

Indication/ field use

Answer 6

Allergic reaction
Anaphylaxis
Dystonic reaction

Question 7

Contraindications

Answer 7

Hypersensitivity

Question 8

Side effects / adverse reactions

Answer 8

Sedation, dries bronchial secretions, blurred vision, HA, palpitations, dizzyness,drowsiness, fatigue, euphoria, hypotension

Question 9

Dose adult

Answer 9

25-50mg IV, IO, IM, PO

Question 10

Dose pedi

Answer 10

1mg/kg IV/ IO/IM/ PO max dose of 50mg

Question 11

Precaution

Answer 11

Caution with patients with severe liver disease and acute asthma

Question 12

Drug on drug interactions

Answer 12

Potentiates sedative effects of alcohol, benzos, CNS depressants, and MAOI’s