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Medical Technology - Clinical Hematology > Dinglasan, RJA (2016) > Flashcards

Dinglasan, RJA (2016) Flashcards

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USMLE® Step 1 flashcards
1
Q

All of the following belong to the thrombin sensitive group of coagulations factors:

A

✅ Prothrombin

❎ Fibrinogen, Proaccelerin, Factor 8

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2
Q

When stained with hematoxylin, Charcot-Leyden crystals appear:

A

Black

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3
Q

The prothrombin time (PT) screens for deficiencies of factors:

A

III, VII (3, 7)

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4
Q

After centrifugation of a blood specimen contained in a capillary tube, the platelets and the leukocytes may be found in the:

A

Third layer

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5
Q

Which of the following statements are true regarding platelets:

  1. It is a non-nucleated cell that contained granules in the cytoplasm;
  2. It originated from the bone marrow;
  3. It came from the fragments of the megakaryocyte nucleus;
  4. It appears similar to common debris on a blood smear
A

1, 2, and 4

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6
Q

The granule containing central part of the platelets is called:

A

Granulomere

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7
Q

When a blood smear is prepared from a heparinized specimen and Wright-stained, the color of the background will be:

A

a. Red
b. Black
c. Pink
D. Blue

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8
Q

Platelet count estimation is done by counting the number of platelets in:

A

10 OI fields

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9
Q

The factor that is depressed by Vit. K antagonists but is not detected by the PT:

A

Factor IX

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10
Q

The bleeding time is:

A

The time it takes for a standard wound to stop bleeding.

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11
Q

The APTT reagent consists of two component, which are:

A

A platelet substitute and an activator

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12
Q

What is the correct order of draw?

A

Blood culture tube, blue top, red top, green top, lavander top, gray top (BCRHES)

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13
Q

If the patient has a weak blood vessel, most probably his bleeding time is:

A

Abnormally prolonged

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14
Q

Which of the following test results is expected on a patient with hyprofibrinogenemia?

A

Thrombin time: proglonged;

Reptilase time: prolonged

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15
Q

Which of the following is a glycoprotein produced by the liver and is considered as the major inhibitor of blood coagulation?

A

Protein C

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16
Q

Which of the following stains is helpful in the diagnosis of suspected erythroleukemia?

A

PAS (Periodic Acidic Schiff)

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17
Q

The cells which are normally found within the bone marrow are:

A

Pronormoblast, Basophili normoblast, Polychromatophilic normoblast, Orthochromic normoblast, Reticulocyte

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18
Q

In Rh deficiency syndrom, the characteristic poikilocyte seen is:

A

Stomatocyte

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19
Q

These inclusion bodies are probably microtubules remaining from a mitotic spindle interpreted as evidence of abnormal erythropoiesis:

A

Cabot rings

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20
Q

The precipitates of hemoglobin that result from oxidant stress and is found primarily with hemolytic anemia:

A

Heinz bodies

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21
Q

Flaujeac factor is otherwise known as:

A

HMWK

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22
Q

What si the name of the macrophage present in the liver?

A

Kupffer cells

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23
Q

Regarding hemoglobin, which of the following statements are true:

  1. Synthesis of hemoglobin begins in the rubricyte stage;
  2. Hemoglobin is eosinophilic;
  3. The hemoglobin molecule is normally found in the plasma;
  4. NOTA
A

1 and 2

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24
Q

The main purpose of potassium ferricyanide in the cyanmethemoglobin method is to:

A

Oxidize hemoglobin to methemoglobin

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25
Q

In the hematocrit determination procedure, one should seal the capillary tubes at the:

A

End of the tube with the colored ring

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26
Q

Which of the following instruments use the optical methodology:

  1. Fibrometer
  2. Electra 750
  3. Coag-A-Mate X2
  4. Koagulab 40-A
A

2, 3, and 4

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27
Q

When thrombin binds with with thrombomodulin on the endothelial cell surface, thrombin can:

A

Activate Protein C

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28
Q

Hagemen factor may otherwise be called as:

A

Factor XII (12)

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29
Q 
Macrocytic RCs are expected in the following disorder:
A. Liver dse
B. Megaloblastic anemia
C. Leukemia
D. AOTA
A

Liver dse and Megaloblastic anemia

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30
Q

The following statements refer to the characteristics of a plasma cell:

A

It has a deep blue and nongranular cytoplasm;
It has an eccentric nucleus surrounded by a perinuclear clear zone
The nucleus contains blocks of chromatin in a cartwheel configuration

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31
Q

Jordan’s anomaly is assoc. with:

A

Muscle dystrophy

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32
Q

The most appropriate site for bone marrow studies in adults is:

A

Posterior superior iliac crest

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33
Q

In which stage of erythrocytic maturation does hemoglobin formation begin?

A

Polychromatic normoblast

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34
Q

In the cascade theory of blood coagulation, the factors react in which order?

A

XII, XI, IX, VII, X (12, 11, 9, 8, 10)

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35
Q

The intrinsic pathway of coagulation involves:

A

Factor XII (12)

36
Q

Three tubes containing CSF coming from a patient was received in the laboratory. Which one of these tubes should delivered to the Hematology area?

A

Tube no. 3

37
Q 
RBC = 4.19 x 10^12/L
Hct = 0.40 L/L
Hgb = 11.98 g/dL

MCV?

A

96.577 fL

38
Q 
RBC = 4.19 x 10^12/L
Hct = 0.40 L/L
Hgb = 11.98 g/dL

MCHC?

A

29.95 g/dL

39
Q

A medtech wants to know the Hct of a patient but the only date available are the RCC and the MCV. To determine the Hct, the MT should:

A

Multiple the MCV by the RCC, and then divide the product by ten. (MCVxRCC/10)

40
Q

In the Factor X (10) deficiency, a prolonged PT or APTT is corrected by the addition of:

A

Aged plasma, Aged serum, and Fresh serum

41
Q

Which of the folliwing test results is expectedly abnormal in Christmas dse?

A

APTT

42
Q

In anemic conditions, there is a tendency to bleed bc:

A

RBCs add bulk and structural integrity to the fibrin clot

43
Q

The ff. tests will demonstrate normal results in a patient with Factor VII (7) defiency:

A

APTT, TT, Plt count

44
Q

The following are components of the nonspecific type of immunity:

A

Complement system, neutrophils, macrophages

45
Q

Muramidase (lysozyme) is present in:

A

Neutrophils and monocytes

46
Q

Ident which one will demonstrate a low serum ferritin test result:

A

Iron deficeincy anemia (IDA)

47
Q

Which of the following cells is the largest in the bone marrow?

A

Mehakaryocyte

48
Q

The coagulation factors that require Vit. K for their production include:

A

Stuart factor (10), Factor IX (9), Fibrinogen (1)

49
Q

The most abundant circulation blood cell in the peripheral blood is:

A

Neutrophil

50
Q

This is the process by which an antibody or complement component attaches itself to foregin materials thereby triggering or enhancing phagocytosus by leukocytes:

A

Opsonization

51
Q

Paroxysmal Nocturnal Hemoglobinuria (PNH) may be detected through:

A

Ham’s Acidified Serum Test, Sugar Water Test, Flow Cytometry

52
Q

The following statements describes the lymphocytes on a Wright-stained smear:

A

Slightly larger then RBCs and with a round nucelus

53
Q

To properly mix the blood and the AC in the light blue top tube, the medtec must inver the tube:

A

3 to 4 times

54
Q

When the absolute numbers of each of the individual leukocyte types are totaled, the sum should be equal to:

A

WBC count

55
Q

Lipemia may affect which hematologic parameters?

A

Hemoglobin and MCH

56
Q

Inactivation of Factors Va and VIIIa are caused by:

A

Activated Protein C

57
Q

In the granulocytic series of maturation, what is the last stage to undergo mitosis?

A

Myelocyte

58
Q

If the MT multiplies the RBC count of a nomarl individual by 3, the resulting value will most probably reflect the:

A

Hemoglobin of the patient

59
Q

The nuclear parachromatin of the lymphocyte tends to stain light purple with deep purple heterochromatin, giving the appearance of:

A

Crushed velvet

60
Q

The primary inhibitor of the fibrinolytic system is:

A

Alpha 2 - antiplasmin

61
Q

Which of the following disorder is characterized by sever capillary damage following meningococcal septicemia and may also be seen in streptococcal and pneumococcal infections?

A

Waterhouse-Friderichsen syndrome

62
Q

Clinical conditions associated with DIC include:

A

Snake bites, Sepsis, Acute Promyelocytic Leukemia

63
Q

Which of the following blood vessel component is a receptor fro thrombin??

A

Thrombomodulin

64
Q

Which of the following erythroid maturation stages would be the most sensitive to erythropoietin stimulation?

A

CFU-E

65
Q

The patients APTT failed to correct after addition of normal fresh plasma. What would be the most probable case?

A

Circulation ACs

66
Q

The first drop of blood in the skin puncture should be wiped away to prevent contamination of the specimen in order to:

A

Facilitate the free flow of blood

67
Q

This is the term used to describe a condition where the red cells vary in size greatly.

A

Anisocytosis

68
Q

What is the critical value for hemoglobin level?

A

< 70 g/L and > 200 g/L

69
Q

This RC inclusion is composed of ferric iron and appear as bluish green-staining bodies in Prussian blue reactions.

A

Siderotic granules

70
Q

The “pince-nez” appearance of neutrophil nucleus may be seen in:

A

Pelger-Huet anomaly

71
Q

This explains the effect of pH on the oxygen release mechanism og Hemoglobin

A

Bohr effect

72
Q

If the phlebotomist has no other alternative than to extract blood from an intravenous site, he should as the nurse to stop the infusion for a period of:

A

2 minutes before drawing blood specimen

73
Q

The granulation in this anomaly results from an abnomal deposition and storage of mucopolysaccharides:

A

Alder-Reily anomaly

74
Q

Peroxidase containing granules are present in the following granulocytes:

A

Promyelocytes, myelocytes, metamyelocytes, band and segmented neutrophils

75
Q

PBC basophilic stippling may be found in:

A

P5N Deficiency, Thalassemia, and Lead Poisoning

76
Q

Which of the following is considered as the storage site fro vWF in the blood vessel cells?

A

Weibel-Palade bodies

77
Q

The mean plasma concentration of fibrinogen is:

A

200 - 400 mg/dL

78
Q

In an electronic cell counter, clumped platelets may interfere with which of the ff. lab. results?

A

WBC count and Platelet count

79
Q

The primary granules of the neutrophils contain:

A

MPO

80
Q 
WBC = 18, 700/mm3
Neutro = 79%
Eos = 7%
Baso = 1%
Lympo = 10%
Mono = 3%
A

Relative eosinophilia, Relative neutrophilia, absolute neutrophilia, absolute eosiniphilia, relative lymphocytopenia

81
Q 
WBC = 13, 900/mm3
Neutro = 71%
Lympo = 25%
Eos = 2%
Mono = 2%
A

Absolute neutrophilia, Relative neutrophilia

82
Q

3 to 4 sickle cells seen per OIO

A

Positive

83
Q

5 to 8 RCs with Howell-Jolly bodies seen per OIO

A

Positive

84
Q

15 to 16 thorn cells per OIO

A

3+

85
Q

Complete the ff. statement: “When Factor XIII (13) is present, the fibrin clot formed is ________ in 5M Urea and _______ when left standing for _______.

A

Insoluble, 1% Monochloeoacetic acid, 24 hours.

Medical Technology - Clinical Hematology (1 decks)

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