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Protein Biochemistry > Digestive system > Flashcards

Digestive system Flashcards

1
Q

Type of cells in salivary gland

A
  1. Acinar cells (volume)
  2. duct cells (composition of saliva)
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2
Q

parts of stomach

A
  1. cardia
  2. fundus
  3. body
  4. antrum
  5. pyloric
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3
Q

parts of small intestine

A
  1. duodenum
  2. jejunum
  3. ileum
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4
Q

secretion of pancreatic juices takes place in

A

duodenum

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5
Q

parts of large intestine

A
  1. ascending colon
  2. transverse colon
  3. descending colon
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6
Q

part where small intestine opens in large intestine

A

caecum

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7
Q

sphincter between esophagus and stomach

A

gastroesophageal sphincter

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8
Q

explain diphyodont

A

condition where milk teeth are replaced by permanent teeth

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9
Q

explain thecodont

A

teeth embedded in the socket of jaw

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10
Q

types of teeth with their function

A

4 types of teeth (heterodont)
1. incisor ( front, for cutting)
2. canine (sharp pointed teeth)
3. pre-molar ( known as cheap teeth, used for grinding and crushing)
4. molar (same as above)

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11
Q

teeth formula

A

2123 - adult
2103 - child (premolar absent)

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12
Q

types of salivary gland

A
  1. parotid (largest gland, 20% contribute, 1 in pair)
  2. submandibular (starts 4m lower jaw to 2nd molar, 70% contribute)
  3. sublingual (below tongue, 5% contribute)
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13
Q

saliva pH

A

6.7 (acidic)

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14
Q

amount of saliva secreted everyday

A

1 - 1.5 liters

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15
Q

components present in saliva

A
  1. mucus (s Ig A) mucin protein (protect the lining of stomach)
  2. chloride ion (initiates fluid secretion process)
  3. lysozyme (antibacterial)
  4. lactoferrin (proline rich, protect teeth, binds with Fe, bacteriostatic)
  5. Ptyalin (also known as salivary alpha amylase)
  6. lingual lipase
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16
Q

about ptyalin

A
  1. breaks alpha 1,4 bond of carbohydrate
    eg: starch, glycogen
  2. But can’t break alpha 1,6 bond of carbohydrate
    eg: sucrose
  3. needs chloride ion , ph 6.5 for proper functioning
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17
Q

movement of food in gut is known as

A

peristaltic movement, where both longitudinal and circular muscles moves together to move food

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18
Q

histology of gut

A
  1. serosa (outermost)
  2. muscularis
  3. submucosa
  4. mucosa (innermost)
  5. lumen
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19
Q

sphincter between pyloric and duodenum

A

pyloric sphincter

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20
Q

components of mucosa

A
  1. epithelial cells
  2. basement membrane
  3. lamina propria (connective tissue where blood vessels are present)
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21
Q

components of submucosa

A

Meissner’s nerve plexus (controls glandular secretions, alters electrolyte and water transport, and regulates local blood flow)

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22
Q

components of muscularis

A
  1. circular muscles
  2. longitudinal muscles
  3. myenteric plexus/ Auerbach’s plexus (responsible for the peristaltic movement of the bowels)
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23
Q

cells present in fundus of stomach

A

mucus cells/ goblet cells (secrets mucus)

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24
Q

cells present in the ‘body’ of stomach

A
  1. oxyntic cells
  2. chief cells/parietal cells
  3. G cells/ goblet cells (present very less)
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25
Q

cells present in the antrum of stomach

A
  1. G cells/goblet cells (releases gastrin) (more in no.)
  2. oxyntic cells and chief cells present less in no.
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26
Q

secretion of oxyntic cell and chief cell

A

oxyntic cell - hcl + intrinsic factor
chief cell - pepsinogen (inactive form of enzyme)

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27
Q

function of intrinsic factor

A

helps in absorption of vitamin B-12.

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28
Q

Why is Vit B -12 required?

A
  1. helps in RBC maturation
  2. helps in lymphocyte maturation
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29
Q

function of HCl

A
  1. Helps in the absorption of Fe
  2. kills bacteria
  3. provides acidic medium for the activation of enzymes
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30
Q

where are gastric glands located

A

in the lining of the stomach

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31
Q

what are ECLs?

A
  1. ECL are enterochromaffin like cells present in the form of patches in the g cells of Gastric gland
  2. neuroendocrine cells
  3. releases Histamine upon the action of gastrin which is released from g cells
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32
Q

inhibitors of proton pump

A

omeprazole
pantoprazole

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33
Q

explain the release of histamine in detail

A
  1. gastrin binds to the “G protein coupled receptor”
  2. which releases adenyl cyclase
  3. which releases cAMP
  4. Which in turn releases protein kinase A (PKA)
  5. which releases histamine
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34
Q

what is the role of histamine released in humans

A

regulates the acid secretion by oxyntic cells in the stomach

35
Q

explain the process of acid secretion controlled by histamine

A
  1. histamine released from ECL binds to H2R (histamine receptor)
  2. which leads to the release of adenyl cyclase to cAMP to PKA
  3. This leads to the OPENING of proton pump and conversion of H2O and CO2 into H2CO3 then to hydrogen ion and hydrogen carbonate ion in the presence of carbonic anhydrase.
  4. hydrogen ion so released leaves the chief cell and potassium ion enters in its place through proton pump which were opened
  5. HCO3- ion leaves the cell via band III and chloride ion enters in its place.
  6. Cl - ion leaves the chief cell and forms HCl in the lumen
36
Q

what is band 3

A

major integral protein which helps in the ion transport and maintenance of protein-protein interactions.

37
Q

pH of empty stomach and pH of stomach when full

A

empty - pH 5
Full - 1.5

38
Q

reasons for ulcers in stomach

A
  1. barrier destroy
  2. alcohol consumption
  3. NSID (non steroidal inflammatory drug)
  4. infection (helicobacter pylori)
39
Q

layers of barriers of stomach

A
  1. Mucus (mucin protein)
  2. Trefoil peptide
  3. H2CO3 (weak acid)
40
Q

lengths of parts of small intestine in their descending order

A

ileum> jejunum>Duodenum

41
Q

cells found in duodenum in the crypts of Lieberkühn

A

i cell (secrets cholecystokinin/ CCK, Pancreozymine (Pz) ]
S cell - (secretin)
Paneth cells (secrets defensin, lysozyme; both of which are antimicrobial peptide)
Brunner’s gland - mucus rich in bicarbonate and
enterokinase (enzyme)

42
Q

name the component present in ileum and its function

A

Payer’s Patches (which secrets B lymphocyte, T lymphocyte and phagocytic cells)

43
Q

bile is released from which duct

A

hepatopancreatic duct (common passage for left and right lobe of liver)

44
Q

cystic duct brings bile secretion from which organ?

A

gall bladder

45
Q

components of bile

A
  1. cholesterol
  2. Bile pigments
  3. bile salts
  4. enzymes absent
  5. pale yellow in colour
  6. 500 ml production in a day
46
Q

bile pigments

A

bilirubin and biliverdin

47
Q

full form of GERD

A

Gastroesophageal reflux disorder (backward movement of food from stomach to esophagus)

48
Q

examples of bile salts

A

taurocholic acid and Glycocholic acid and taurochenodeoxycholic acid and glycochenodeoxycholic acid

49
Q

facts about bile

A

continuously formed, excess bile stored in gall bladder, bile from liver contains 30% water whereas bile from gall bladder contains 10% water.

functions at pH 8

50
Q

Functions of bile

A
  1. Reduces surface tension
  2. increases surface area for fat absorption
  3. Helps in emulsification of fat
  4. Amphiphatic in nature.
51
Q

secretion of pancreatic juice in a day and pH

A

1-1.5 liters a day at pH 8

52
Q

enzymes of pancreas

A
  1. pancreatic alpha amylase
  2. proteases
  3. Lipases
  4. DNAse
  5. RNAse
53
Q

types of proteases present in pancreatic juice

A
  1. trypsinogen
  2. chymotrypsinogen
  3. pro- elastase
  4. Procarboxypeptidase

All the proteases secreted are present in inactive form called zymogens

54
Q

action on chyme after being released from stomach

A
  1. acidic food enters duodenum
  2. acidity sensed by I cells
  3. activates CCK and Pz (at low conc.) from Brunner’s gland
  4. which in turn activates gall bladder via IP3 (2ndry messenger) and S cells
  5. which activates bile (pH 8)
  6. S cells secretes secretin
  7. secretin activates pancreas via cAMP (2 messenger)
  8. Pancreas activates f cells and release bicarbonates
55
Q

condition when CCK AND PZ are released more in amount

A
  1. CCK AND PZ stimulates pancreas
  2. which secrets pancreatic juice
56
Q

enzyme which helps in the digestion of collagen

A

pepsin from chief cells

collagen is a major constituent of meat

57
Q

action of trypsin

A

act on the basic amino acid

58
Q

action of Chymotrypsin

A

act on the C terminal of aromatic amino acid

59
Q

action of elastase

A

act on the C terminal of aliphatic amino acid

60
Q

action of carboxypeptidase

A

carboxypeptidase A acts on the aromatic amino acid

carboxypeptidase B acts on the Basic amino acid

61
Q

how is trypsin activated?

A
  1. enterokinase from crypts of Lieberkühn is released
  2. acts on trypsinogen
  3. Active form trypsin is generated
62
Q

which enzyme activates all the inactive zymogens?

A

trypsin

63
Q

who all does the digestion of carbohydrate

A
  1. salivary alpha amylase
  2. pancreatic secretion
  3. Intestinal enzyme (memrane bound enzymes)
64
Q

After digestion of glycogen and starch by pancreatic alpha amylase converts into

A

In duodenum
1. sucrose
2. Maltose
3. Dextrin
4. Lactose

65
Q

name of intestinal enzymes which acts on the chyme in duodenum

A
  1. Sucrase
  2. Maltase
  3. Alpha Dextrinase
  4. Lactase
66
Q

final products after action of intestinal enzymes

A
  1. sucrase into glucose and fructose
  2. Maltase into glucose
  3. Dextrinase into glucose
  4. Lactase into Glucose and galactose
67
Q

where does digestion of proteins occurs?

A

jejunum

68
Q

enzyme that acts on proteins and peptones

A

intestinal enzyme

69
Q

after digestion proteins and peptones are converted into what

A

proteins into amino acid and peptones into dipeptides and tripeptides

70
Q

where does maximum digestion takes place?

A

Duodenum

71
Q

where does maximum Absorption takes place?

A

Jejunum

72
Q

Where does digestion of fats takes place?

A

duodenum

73
Q

triglycerides of fats are converted into what

A

1 monoglycerides and 2 molecules of fatty acid

74
Q

name of the enzyme that acts on the fats

A

Lipases

75
Q

Where does the absorption of different components of food takes place

A

enterocytes of intestine which is supplied by villi which is then followed by microvilli present on the apical surface of jejunum

76
Q

What is SGLT 2

A

Sodium Glucose Co transporter 2 is a secondary active transporter which transports sodium and glucose or galactose

77
Q

explain the absorption of carbohydrate

A

sodium glucose and galactose are transported by SGLT 2 and fructose is transported by GLUT 5 from lumen of intestine into basal side of cell i.e. into the blood circulation.

fructose is transported by facilitated diffusion whereas SGLT is an active transporter

fructose comes in by GLUT 5 and goes by GLUT 2 into blood circulation

78
Q

1 SGLT 2 can transport how many molecules

A

1 glucose
1 galactose
2 sodium ions

79
Q

what happen to sodium transported by SGLT 2

A

3 sodium ions move out and 2 potassium ions enter via Na/K ATPase

80
Q

which carbohydrate will transport in the absence of energy

A

fructose (transported by facilitated diffusion)

81
Q

ion channels through which protein uptake occurs in enterocytes

A
  1. sodium amino acid co transporter ( 5 types) [ transport Na+ and amino acid]
  2. Chlorine amino acid co transporter (2 types) [transport chlorine and amino acid]
  3. NHE (sodium hydrogen exchange) [ transport 1 Na+ in exchange of 1 H+]
  4. Pept-1 (symporter) [ transports H+, Di, tri peptide]
82
Q

Action on Di and tri peptide

A

Di and Tri peptide are acted upon by dipeptidase and tri peptidase converting them into amino acid

These amino acid are transported out from the enterocytes by facilitated diffusion

83
Q
A

Protein Biochemistry (2 decks)

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