Digestion and absorption AAU Flashcards

1
Q

Digestion of various food is by the process of

A

hydrolysis

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2
Q

Digestion is?

A

different types of food are broken in the absorbable units “ principally in the small intestine.

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3
Q

Absorption is ?

A

the products of digestion and vitamins, minerals and water crosses mucosa and enter the blood or lymph

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4
Q

Carbohydrate Digestion the mouth ?

A

Salivary α amylase acts on polysaccharides
starches is hydrolyzed into maltose
not more than 5 %of all the starches will have become hydrolyzed

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5
Q

Carbohydrate Digestion In the stomach ?

A

Salivary α amylase is essentially nonactive once the pH below 4.0.

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6
Q

Carbohydrate Digestion In the intestine?

A

Pancreatic α amylase
the carbohydrates are almost totally converted into maltose and/or other very small glucose polymers before passing beyond the duodenum or upper jejunum.

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7
Q

Products of starch digestion by α amylase ?(3)

A
  1. Disaccharides: maltose.
  2. Trisaccharides: maltotriose.
  3. Short polymesr: α dextrins.
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8
Q

enzymes found in the brush border ?(5)

A
  1. α dextrinase
  2. Maltase
  3. Sucrase
  4. Lactase
  5. Trehalase
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9
Q

α dextrinase:

A

Acts on alpha dextrins, maltose & maltotroise. α dixtrinase also known as isomaltase it hydrolyses 1:6α linkages. along with maltase and sucrase it also breaks down maltotriose and maltose.

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10
Q

Maltase?

A

Acts on maltose to give glucose -glucose

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11
Q

Sucrase ?

A

Acts on sucrose to give glucose =fructose

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12
Q

Lactase?

A

Acts on lactose give glucose + galactose.

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13
Q

Trehalase:

A

Acts on trehalose to give glucose+glucose

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14
Q

The absorbed units of carbs enter

A

portal circulation portal vein.

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15
Q

Glucose absorption On luminal membrane

A

Accomplished by carries for co-transport to inside the cell
Sodium –glucose transports 1 & 2 (SGLT1 & SGLT2).

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16
Q

Glucose absorption On basolateral membrane?

A

(carriers for facilitated diffusion to the ISF). Glucose transporters 1 & 2 (GLUT1 & GLUT2).

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17
Q

The Glucose transporter sensitive to insulin

A

GLUT-4

found in fat & muscle cells

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18
Q

Galactose Absorption?

A

Similar to glucose (i.e.co transported with sodium “secondary active transport”).

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19
Q

Fructose Absorption by

A

Facilitated diffusion that is Independent of Na

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20
Q

Fructose Absorption To enterocytes by

A

GLUT5

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21
Q

Fructose Absorption To interstitial by

A

GLUT2

22
Q

Pentose Absorption

A

Absorbed by simple diffusion

Produced from metabolism of nucleic acids.

23
Q

Protein Digestion In the mouth?

A

No enzyme for digestion.

24
Q

Protein Digestion In the Stomach?

A
Enzymes
gelatinase :  liquefies gelatin 
Pepsin :  It hydrolysis the bond between aromatic amino acids and a second amino acid
Product
polypeptides with very divers sizes.
25
Q

pepsin (activation , inhibition )

A

Pepsinogen in low pH activated to pepsin

Pepsin activity inhibited by alkaline secretion of the pancreas

26
Q

Protein Digestion In the intestine?

A

Enzymes
Pancreatic endopeptidases (Trapsin, chymotrypsin, and elastase)
Pancreatic exopeptidase (Caboxypeptidases A & B)
Product
They produce Di & Tri peptides but not aminoacids( endopeptidases )
Some free aminoacids liberated in the intestinal lumen ( exopeptidase )

27
Q

Endopeptidases act at

A

interior peptide bonds.

28
Q

carboxipeptidases hydrolyses aminoacids at

A

carboxyl and amino ends.

29
Q

proteolytic enzyme found in the brush border ?

A

Aminopeptidases
Carboxipeptidases
Endopeptidases
Dipeptidases

30
Q

digestion of aminoacids occur in three locations

A
  1. Intestinal lumen.
  2. Brush boarder.
  3. Cytoplasm of mucosal
31
Q

Products of Protein Digestion ?

A
  • Free amino acids.
  • Dipeptides.
  • Tripeptides.
32
Q

The absorbed units of protein enter

A

portal circulation

33
Q

Absorption of free Amino Acids ?

A

Co transport with sodium (mainly)

34
Q

Absorption of Dipeptides & Tripeptides?

A

By a mechanism involving hydrogen ions

35
Q

absorption Complete Protein Undigested

A

Occurs in infants for IgA antibodies in milk

by endocytosis

36
Q

Abnormalities of Protein Digestion & Absorption?

A

Absorption of foreign proteins induces antibody formation;

Congenital defects in the mechanism of amino acid absorption

37
Q

Lipid Digestion In the mouth ?

A

Lingual lipase (acts on triglycerides). Lingual lipase digest as much as 30% of triglycerides

38
Q

Lipid Digestion In the stomach ?

A

Gastric lipase. Gastric lipase is of little importance.

39
Q

Lipid Digestion In the intestine (From the liver) ?

A

Bile salts, which cause emulsification and micelle formation

40
Q

Micelle contains ?

A
  1. Fatty acids.
  2. Monoglycerids .
  3. Cholesterol .
41
Q

Lipid Digestion In the intestine ( From the pancreas ) ?

A

Pancreatic lipase & Co lipase .

42
Q

Pro-colipase activated by ……. to colipase

A

trypsin

43
Q

co-lipase act on

A

emulsified fat

tri-glycerides ( HYDROLYSIS 1& 3bonds easily but 2-bondes slowly )

44
Q

co-lipase product

A
  1. Free fatty acids.

2. 2-monoglycerids.

45
Q

Bile salt activated lipase act on ?

A

cholesterol esters, ester of fat soluble vitamins, phospholipids as well as Triglycerides .

46
Q

The absorbed units of fats enter ?

A

portal circulation or lymphatics

47
Q

Fats entering the portal blood have carbons

A

No answer here

48
Q

Fats entering the lymphaties have carbons >(10-12)e.g. long chain free fatty acids and cholesterol.

A

No answer here

49
Q

Chylomicrons

A

Before entering the lymphatic’s, the long chain fatty acids and cholesterol are re-esterified within the cytoplasm of intestinal cells and become coated with protein & phospholipids to from it

50
Q

Chylomicrons are released to lymphatic’s by ?

A

exocytosis.

51
Q

Steatorrhoea

A

Loss of more than 5 grams of fat in stool per day. Steatorhoea is caused by conditions that impairs of Fat Digestion & Absorption

52
Q

Nucleic acids digestion ?

A
  1. Deoxiribonucleases act on DNA and release nucleotides
  2. Ribonucleases act on RNA release nucleotides
  3. Then different nucleases releases pyrimidines and purine bases.