Diffuse Alveolar Hemorrhage Flashcards

1
Q

2 circulations in lung

A

Bronchial (high pressure, low volume)
Pulmonary (low pressure, high capacitance)

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2
Q

Bronchial circulation supplies __

A

Conducting airways (mainstem bronchi until terminal bronchioles)

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3
Q

Bronchial circulation arises from:

A

Aorta

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4
Q

Source of low-grade, chronic and diffuse alveolar hemorrhage

A

Pulmonary circulation

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5
Q

Bleeding in cystic fibrosis is due to:

A

Bronchiectasis

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6
Q

Infection presenting with hemoptysis

A

S. pneumoniae
S. aureus

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7
Q

Timeline of hemosiderin-laden macrophages

A

3 days: first appear
7-10 days: peak
2 months: resolution

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8
Q

Most common ANCA-associated vasculitis presenting with DAH from pulmonary capillaritis

A

MPA

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9
Q

Vessels affected by ANCA vasculitis

A

Small and medium

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10
Q

Necrotizing vasculitis of small- and medium-sized vessels with granulomatous inflammation

A

GPA

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11
Q

Clinical features are chronic rhinitis, sinusitis, OM, nasal cartilage destruction (saddle nose), salivary gland swelling, SG stenosis, tracheobronchial ulceration, parenchymal nodules that may cavitate, DAH

A

GPA

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12
Q

Antibodies in GPA

A

Anti-PR3 (c-ANCA pattern)

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13
Q

Gold standard for diagnosis of GPA

A

Biopsy: vasculitis and capillaritis with necrotizing granulomata, paucity of immune complexes

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14
Q

Antibodies in MPA

A

Anti-MPO (p-ANCA pattern)

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15
Q

Biopsy in MPA

A

PC with neutrophilic infiltration of small arterioles, venues, and capillaries with fibrinoid necrosis

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16
Q

Treatment of ANCA vasculitis

A

Induction with GC and cyclophosphamide for 3-6 months
Maintenance with prednisone, methotrexate, azathioprine for 1-2 years

Others:
Rituximab, IVIg, plasmapharesis

17
Q

Vasculitis limited to lung and kidney

A

Anti-GBM disease

18
Q

Diagnosis of anti-GBM

A

Anti-GBM antibodies in serum and basement membrane of lung and kidney

19
Q

Treatment of anti-GBM

A

CS
Cyclophosphamide
PLASMAPHERESIS in all cases

20
Q

PC with alveolar hemorrhage without renal or other systemic manifestations

A

IPC

21
Q

Differentiates IPC from IPH

A

Lower Hgb, higher ESR in IPC

22
Q

Treatment of IPC

A

Same as ANCA vasculitis

23
Q

Autosomal dominant pulmonary hemorrhage syndrome

A

COPA Syndrome

24
Q

Pathophysiology of COPA Syndrome

A

Dysfunctional autophagy
Th17 skewing and immune dysregulation
Chronic, relapsing and remitting alveolar hemorrhage

25
Q

CT findings of COPA

A

Cystic disease

26
Q

Biopsy of IPH

A

Bland alveolar hemorrhage, absence of inflammation

27
Q

Treatment of IPH

A

CS

Steroid-sparing:
Hydroxychloroquine
Azathioprine

Others:
6-mercaptopurine

28
Q

Cytologic finding in DAH

A

Hemosiderin-laden macrophages

29
Q

Management of massive hemoptysis

A

High PEEP
Double lumen ET
Bronchial artery embolization