Diffuse Alveolar Hemorrhage Flashcards
2 circulations in lung
Bronchial (high pressure, low volume)
Pulmonary (low pressure, high capacitance)
Bronchial circulation supplies __
Conducting airways (mainstem bronchi until terminal bronchioles)
Bronchial circulation arises from:
Aorta
Source of low-grade, chronic and diffuse alveolar hemorrhage
Pulmonary circulation
Bleeding in cystic fibrosis is due to:
Bronchiectasis
Infection presenting with hemoptysis
S. pneumoniae
S. aureus
Timeline of hemosiderin-laden macrophages
3 days: first appear
7-10 days: peak
2 months: resolution
Most common ANCA-associated vasculitis presenting with DAH from pulmonary capillaritis
MPA
Vessels affected by ANCA vasculitis
Small and medium
Necrotizing vasculitis of small- and medium-sized vessels with granulomatous inflammation
GPA
Clinical features are chronic rhinitis, sinusitis, OM, nasal cartilage destruction (saddle nose), salivary gland swelling, SG stenosis, tracheobronchial ulceration, parenchymal nodules that may cavitate, DAH
GPA
Antibodies in GPA
Anti-PR3 (c-ANCA pattern)
Gold standard for diagnosis of GPA
Biopsy: vasculitis and capillaritis with necrotizing granulomata, paucity of immune complexes
Antibodies in MPA
Anti-MPO (p-ANCA pattern)
Biopsy in MPA
PC with neutrophilic infiltration of small arterioles, venues, and capillaries with fibrinoid necrosis