Differential diagnosis and mini-cases - headache, confusion&memory loss, loss of vision, depressed mood, psychosis, dizziness Flashcards
Headache - key history ?
- Onset : acute or chronic ?
- Location : unilateral vs. bilateral ?
- Quality : dull vs. stabbing ?
- Intensity : is it the “worst headache of their life” ?
- Duration, timing : does it disturb sleep?)
- Presence of associated neurologic symptoms : paresthesias, visual stigmata, weakness, numbness, ataxia, photophobia, dizziness, auras, neck stiffness;
- Nausea/vomiting?
- Jaw claudication?
- Recent trauma, dental surgeries?
- Sinusitis symptoms : frontal pain, pain over sinuses ?
- Exacerbating factors : stress, fatigue, menses, exercise, certain foods ?
- Alleviating factors : rest, medications ?
- Patient and family history of headache ?
Headache : Key Physical Exam ?
- Vital signs;
- Inspection and palpation of entire head;
- ENT inspection;
- Complete neurologic exam, including fundu- scopic exam;
What is your differential diagnosis and workup plan ?
21 yo F presents with several episodes of throbbing left temporal pain that last for 2–3 hours. Before onset, she sees flashes of light in her right visual field and feels weakness and numbness on the right side of her body for a few minutes. Her headaches are often associated with nausea and vomiting. She has a family history of migraine.
- Differential diagnosis :
- Migraine headaches - complicated
- Tension headaches
- Cluster headaches
- Pseudotumor cerebri
- CNS vasculitis
- Partial seizure
- IC neoplasm
- Workup plan :
- CBC, ESR
- CT-head, MRI-brain
- LP : CSF analysis
What is your differential diagnosis and workup plan ?
26 yo M presents with severe right temporal head- aches associated with ipsilateral rhinorrhea, eye tearing, and redness. Episodes have occurred at the same time every night for the past week and last for 45 minutes.
- Differetntial diagnosis :
- Cluster headaches
- Migraine headaches - complicated
- Tension headches
- Intracranial neoplasm
- Pseudotumor cerebri
- Workup :
- CBC, ESR
- CT - head, MRI - brain
- LP - CSF analysis
What is your differential diagnosis and workup plan ?
65 yo F presents with severe, intermittent right tem- poral headache, fever, blurred vision in her right eye, and pain in her jaw when chewing.
- Differential diagnosis :
- Temporal arteritis - giant cell arteritis
- Migraine hedache
- Cluster headache
- Tension headache
- Meningitis
- Carotid artery dissection
- Pseudotumor cerebri
- Temporomandibular joint disorder
- Trigeminal neuralgia
- Intracranial neoplasm
- Workup :
- CBC with differential, ESR, CRP
- Temporal artery biopsy
- Fundoscopic exam and visual field testing
- MRI - brain, CT - head
- Doppler U/S - carotid
- LP - opening pressure and CSF analysis
What is your differential diagnosis and workup plan ?
“30 yo F presents with frontal headache, fever, and nasal discharge. There is pain on palpation of the frontal and maxillary sinuses. She has a history of allergies”
- Differential diagnosis :
- Allergic sinusitis
- Bacterial/viral (infectious) sinusitis
- Common cold
- Migraine
- Tension headache
- Meningitis
- Workup :
- CBC with differential, ESR, CRP
- XR - sinuses; CT - sinuses
What is your differential diagnosis and workup plan ?
“50 yo F presents with recurrent episodes of bilateral squeezing headaches that occur 3–4 times a week, typically toward the end of her work day. She is ex- periencing significant stress in her life and recently decreased her intake of caffeine”
- Differential diagnosis :
- Tension-type headaches
- Caffein-withdrawal associated headaches
- Migraine
- Depression
- Hypertension
- Cluster headaches
- Pseudotumor cerebri
- Intracranial neoplasm
- Workup :
- CBC with differential, CRP, ESR
- CT-head, MRI-brain, electrolytes
What is your differential diagnosis and workup plan ?
“35 yo M presents with sudden severe headache, vomiting, confusion, left hemiplegia, and nuchal rigidity”
- Differential diagnosis :
- Subarachnoid hemorrhage
- Stroke - hemorrhagic/ischemic
- Meningitis
- Encephalitis
- Migraine - complicated
- Vertebral artery dissection
- Intracranial venous thrombosis
- Acute hypertension
- Intracranial neoplasm
- Workup
- CT - head, no-contrast
- MRI - brain, MR venography
- CBC with differential
- INR, PT, aPTT
- Glucose, U&E, BUN
- Urinalysis, urine toxicology
- LP - CSF analysis
What is your differential diagnosis and workup plan ?
“25 yo M presents with high fever, severe headache, confusion, photophobia, and nuchal rigidity”
- Differential diagnosis :
- Meningitis
- Encephalitis
- Migraine
- Subarachnoid hemorrhage
- Sinusitis
- Intracranial/epidural abscess
- Workup :
- MRI - brain, CT - head, no contrast
- CBC with differential, CRP
- Blood culture, Urinalysis and culture
- LP - CSF analysis (cell count, protein count, glucose) and culture, opening pressure measurement
What is your differential diagnosis and workup plan ?
“18 yo obese F presents with a pulsatile headache, vomiting, and blurred vision for the past 2–3 weeks. She is taking OCPs”
- Differential diagnosis :
- Pseudotumor cerebri
- Migraine
- Tension headaches
- Cerebral venous thrombosis
- Stroke
- Subarachnoid hemorrhage
- Workup :
- LP - opening pressure, xanthochromia
- CBC with differential, CRP
- INR, PT, aPTT, BT
What is your differential diagnosis and workup plan ?
“57 yo M c/o daily pain in the right cheek for the past month. The pain is electric and stabbing in character and occurs while he is shaving. Each episode lasts 2–4 minutes.”
- Differential diagnosis :
- Trigeminal neuralgia
- Cluster headaches
- Tension headache
- Migraine
- TMJ disorder
- Intracranial neoplasm
- Workup :
- CBC
- ESR
- MRI - brain
What are some useful tips for a good “headache-interview” ?
- Let the patient tell the headache story in his or her own words before asking more directed and focused questions;
- Patients often seek medical care due to concern about a brain tumor or other serious diagnosis => PEARLS;
- First, correctly classify whether the headache is old or new.
- Cardinal symptom features: onset, duration, frequency, pain character, location, radiation, associated features, precipitating and alleviating factors;
- Always ask about change in frequency or character of chronic headache !
- Remember about alarm syptoms;
What are the alarming symptoms that always indicate serious diagnosis ?
- Visual loss => acute-angle closure glaucoma, giant cell arteritis;
- Prolonged visual aura => arterio-venous malformation;
- Dysequilibrium => stroke, brain tumor;
- Confusion or lethargy => meningitis, encephalitis, brain tumor, brain abscess;
- New-onset seizure => stroke, encephalitis, brain tumor;
Confusion/Memory loss - key history ?
- Must include history from family members/caregivers when available;
- Detailed time course of cognitive deficits (acute vs. chronic/gradual onset);
- Associated symptoms (constitutional, incontinence, ataxia, hypothyroid symptoms, depression);
- Screen for delirium (waxing/waning level of alertness);
- Falls, medications (and recent medication changes);
- History of stroke or other atherosclerotic vascular disease, syphilis, HIV risk factors, alcohol use, vitamin B12 deficiency;
- Family history of Alzheimer’s disease or other neurologic disorders;
Confusion/Memory loss - physical examination
- Vital signs;
- Complete neurologic exam, including mini-mental status exam and gait;
- General physical exam, including ENT, heart, lungs, abdomen, extremities;
What is your differential diagnosis and workup plan ?
“81 yo M presents with progressive confusion for the past several years accompanied by forgetfulness and clumsiness. He has a history of hypertension, diabe- tes mellitus, and 2 strokes with residual left hemi- paresis. His mental status has worsened after each stroke (stepwise decline in cognitive function)”
- Differential diagnosis :
- Vascular dementia - multiinfarct dementia or diffuse white matter disease
- Alzheimer’s disease
- Normal pressure hydrocephalus
- Chronic subdural hematoma
- Intracranial neoplasm
- Depression
- Vitamin B12 defficiency
- Hypothyroidism
- Neurosyphilis
- Workup plan :
- MRI - brain, CT - head
- Doppler US - carotid
- Beck’s depression
- Vitamin B12 serum level
- TSH, T4
- VDRL, RPR
- LP - CSF analysis
What is your differential diagnosis and workup plan ?
“84 yo F brought by her son c/o forgetfulness (eg, forgets phone numbers, loses her way back home) and difficulty performing some of her daily activities (eg, bathing, dressing, managing money, using the phone). The problem has progressed gradually over the past few years”
- Differential diagnosis :
- Alzheimer’s disease
- Vascular dementia
- Depression
- Hypothyroidism
- Chronic subdural hematoma
- Normal pressure hydrocephalus
- Intracranial neoplasm
- Vitamin B12 defficiency
- Neurosyphilis
- Workup :
- CBC with differential
- MRI - brain, CT - head
- TSH, T4
- Vitamin B12 serum level
- VDRL, RPR
- Beck’s depression inventory
- LP - CSF analysis
What is your differential diagnosis and workup plan ?
“72 yo M presents with memory loss, gait disturbance, and urinary incontinence for the past 6 months”
- Differential diagnosis :
- Normal pressure hydrocephalus
- Alzheimer’s disease
- Vascular dementia
- Chronic subdural hematoma
- Intracranial neoplasm
- Depression
- B12 deficiency
- Neurosyphilis
- Hypothyroidism
- Workup :
- CT—head
- MRI—brain
- LP—opening pressure and CSF analysis
- Serum B12
- VDRL/RPR
- TSH