Diebel Week 4 Flashcards
1
Q
Naive CD4+ –> ? –> Treg
A
IL-2, TGF-beta –> activation of FOXP3
2
Q
Naive CD4+ –> ? –> Th17
A
IL-1, IL-6, IL-23, TGFbeta –> RORgamma
3
Q
Naive CD4+ –> ? –> Th2
A
IL-4 –> GATA3
4
Q
Naive CD4+ –> ? –> Tfh
A
IL-6, IL-21 –> BCL-6
5
Q
Naive CD4+ –> ? –> Th1
A
IL-12, IFNgamma, IL-18 –> T-Bet
6
Q
t(9,22)
A
CML (bcr-abl hybrid)
7
Q
t(8,14)
A
Burkitt lymphoma (c-myc activation)
8
Q
t(11,14)
A
mantle cell lymphoma (cyclin D1 activation)
9
Q
t(15,17)
A
M3 type of AML (responsive to all-trans retinoic acid)
