Diebel Review Sheet

Question 1

Function of IL-3:

Answer 1

-Growth factor for hematopoietic cells. Important for the proliferation of myeloid progenitor cells.

Question 2

Function of IL-10:

Answer 2

Anti-inflammatory, blocks the generation of Th1 CD4+ T cells.

Question 3

Function of IL-12:

Answer 3

Important factor in inducing the production of Th1 CD4+ T cells. Induced IFNgamma production by Th1 CD4+ T cells and NK cells. Enhances NK cell and CD8+ cytotoxic T cell activity.

Question 4

Function of IL-8:

Answer 4

Chemokine that functions primarily as a chemoattractant and activator of neutrophils

Question 5

Function of IL-2:

Answer 5

Stimulates proliferation and differentiation of mature T and B cells. (MATURE)

Question 6

Function of IL-7:

Answer 6

Growth factor for T and B cell progenitors (IMMATURE)

Question 7

Function of IL-1:

Answer 7

Causes fever and acute inflammation. Activates endothelim to express adhesion molecules.

Question 8

Function fo IL-4:

Answer 8

Promotes naive CD4+ T cell differentiation to Th2 cells. Induces B cell class switching to IgE.

Question 9

Function of IL-6:

Answer 9

Causes fever and stimulates production of acute-phase proteins

Question 10

Function of IL-5:

Answer 10

Induces eosinophil formation and differentiation. Enhances B cell class switching to IgA.

Question 11

T cells can make interleukins IL1-IL-8, IL-10, IL-12 except. . .

Answer 11

IL-1 and IL-7

Question 12

Which HLAs display protein produced endogenously?

Answer 12

HLA-A, HLA-B, HLA-C, HLA-E

Question 13

Which HLAs display protein produced exogenously?

Answer 13

HLA-DO, HLA-DM, HLA-DR, HLA-DQ, HLA-DP

Question 14

Which HLAs regulate the display of protein fragments within MHC II molecules? How?

Answer 14

HLA-DM catalyzes the exchange of antigenic peptide for the CLIP. HLA-DO regulates HLA-DM

Question 15

What is CD3?

Answer 15

Signaling chains of TCR

Question 16

What is CD79a/CD79b?

Answer 16

Signaling chains of BCR

Question 17

What is CD19?

Answer 17

Part of the B cell co-receptor with CD21 and CD81. Critical for regulating B cell development, activation and differentiation.

Question 18

What is CD8?

Answer 18

Co-receptor for MHC I -restricted T cell activation

Question 19

What is CD44?

Answer 19

Involved in lymphocyte activation and homing to lymphoid tissues. Important marker of early T cell development in the thymus. –> If you lack this, you’ll have a hard time making it to the thymus

Question 20

What is CD25?

Answer 20

IL-2 receptor protein. By itself it is just the alpha-chain (low affinity) receptor. When complexed with beta and gamma chains it become a high affinity receptor.

Question 21

What is CD117?

Answer 21

c-kit

Stem-cell factor receptor. Important for the development of hematopoietic progenitors.

Question 22

What is CD4?

Answer 22

Co-receptor for MHC II-restricted T cell activation

Question 23

What is CD40?

Answer 23

Provides essential co-stimulatory signals for B cell activation, proliferation, differentiation and isotope switching. Stimulates cytokine production by macrophages and dendritic cells. Promotes licensing by dendritic cells

Question 24

What is CD80/CD86?

Answer 24

Binds CD28 and is important for co-stimulation of naive T cell activation. Binds CTLA-4 and inhibits T cell activation.