Diarrhoea Flashcards
1
Q
Osmotic diarrhoea
A
When solutes left in gut lumen. Could be due to poorly absorbed solute e.g. sorbitol OR malabsorption e.g. lactose intolerance where lactose remains in the lumen. This draws h2o out of ECF into gut lumen to equalise osmolarity.
Stops when fasted
2
Q
Secretory diarrhoea
A
Abnormal secretion of h2o + salts in LI. Absorption of Na is impaired by villi + secretion of Cl from crypts is increased e.g. cholera - toxin - activates adenyl cyclase - increased cAMP - Cl channels open - h2o + Cl leave cell into gut lumen
3
Q
Treatment
A
ORS - based on principle that absorption of Na (therefore h2o) is enhanced by active absorption of glucose. Uses glucose linked Na transport as this still works when other pathways may not.
