Diarrhea/Constipaton Flashcards
what condition remains one of the MC causes of mortality in developing countries - Particularly infants?
acute infectious diarrhea
definition of diarrhea?
- Passage of abnormally liquid or unformed stools
- Increased frequency - (+3 poos/day)
- Stool weight >200 g/24 h
difference between acute, persistent, and chronic diarrhea?
- Acute - < 2 wks
- Persistent - 2 – 4 wks
- Chronic - > 4 wks
MCC of acute diarrhea?
- infectious agents (viral or bacterial)
- Often accompanied by vomiting, fever, and abdominal pain
- other causes: meds, Toxic ingestions, Ischemia, Food indiscretions
Infectious Agents causing acute diarrhea are MC acquired by?
-
Fecal - oral transmission
- Ingestion of food or water contaminated with pathogens from human or animal feces - Disturbances of flora by abx = overgrowth of pathogens (C. diff)
Five high – risk groups in the United States
- travelers
- consumers of certain foods - Follows food consumption at a picnic, banquet, or restaurant
- Immunodeficient persons
- Daycare attendees and their family members
- Institutionalized persons
pathogen of “traveler’s diarrhea”
E Coli & Giardia lamblia
pathogens causing diarrhea from chicken?
Salmonella, Campylobacter, or Shigella
pathogen in undercooked hamburger causing diarrhea?
E. Coli
pathogen in fried rice or other reheated food causing diarrhea?
B cereus
pathogen in dairy, produce, meats, eggs, salads that have been left out at room temp for too long causing diarrhea?
S. aureus
pathogen from eggs causing diarrhea
Salmonella
pathogen from undercooked shellfish causing diarrhea?
vibrio
pathogen from uncooked foods, lunch meat or soft cheeses causing diarrhea?
listeria
pathogen from improperly stored food/ canned food causing diarrhea?
Clostridium Botulinum
higher incidence of diarrhea in pregnant women if they consume what pathogen/foods?
Listeria (uncooked foods, lunch meat or soft cheeses)
pathogens from Daycare attendees and their family members causing diarrhea?
Shigella, Giardia, rotavirus, Hepatitis A
One of the MC nosocomial infections/pathogen causing diarrhea
C. diff
difference between inflammatory or noninflammatory diarrhea?
- Acute noninflammatory diarrhea
- Watery, nonbloody.
- mild, self-limited.
- Caused by a virus or noninvasive bacteria
- Associated with periumbilical cramps, bloating, n/v
- Disrupts normal absorption and secretory process in the small intestine
- Diagnostic evaluation is limited to pts w/ diarrhea that is severe or persists beyond 7 d - Acute inflammatory diarrhea
- Fever and bloody diarrhea (dysentery)
- Usually caused by an invasive or toxin-producing bacterium.
— causing colonic tissue damage - b/c in colon, smaller volume
— LLQ cramps, urgency, tenesmus
- requires stool bacterial cx (including E coliO157:H7) in all and testing as clinically indicated for C. diff toxin, and ova and parasites
Dysregulation of the small bowel d/t infections lead to ?
watery diarrhea in large volume
- abd. cramping, bloating, gas, wt loss
- Fever rarely a significant sx
- Stool does not contain occult blood or inflammatory cells
MC cause of watery diarrheas
Enteric Viruses
what functions as a fluid/enzyme secretory and nutrient-absorbing organ
The small bowel
what mainly functions to absorb fluid and salt and to excrete potassium
large bowel
presentation of dysfunctional large bowel?
- frequent, regular, small-volume, painful bowel movements
- F and bloody/mucoid stools are common
- RBC and inflammatory cells can be routinely see on stool smear
what are more common causes of inflammatory, large intestinal diarrhea
bacterial pathogens
Most foodborne infections will typically manifest as ?
a mixture of diarrhea, nausea, vomiting, and abdominal discomfort
Ingested preformed toxins (staph. aureus and bacillus cereus) cause illness within ?
hours of exposure (gen. 1-6hrs)
Ingested pathogens which produce toxins (enterotoxigenic E. Coli) or directly damage or invade across epithelial cell wall (Salmonella, Shigella, Campylobacter) usually result in sx when?
24 hours or longer
ingested Protozoal pathogens (cryptosporidium, Giardia) will show sx when?
7 days
over ⅓ of GI viral outbreaks
readily transmitted
usually household/community spread
symptoms begin 24-48 hours after exposure and resolve in 48-72 hours
this incubation period is associated with what pathogens?
Norovirus and other enteric viruses
parasitic cause
daycares, mountainous streams
endemic areas, community swimming pools
7-14 days after exposure
can last for weeks and turn into chronic
this incubation period is associated with what pathogens?
Giardia, cryptosporidium, entamoeba hystolytica
- typically occur in the setting of abx therapy
- may take up to 1 month AFTER abx therapy; most within 2 wks
- though virtually any can predispose
this incubation period is associated with what pathogens?
Clostridioides (formerly Clostridium) Difficile
what abx are most frequently implicated to cause C. diff later on after abx therapy?
fluoroquinolones, clinda, cephalo, PCNs
Hospitalization is required in patients with diarrhea if they exhibit what s/s?
severe dehydration, organ failure, marked abdominal pain, and or altered mental status
what % of acute noninflammatory diarrhea is self-limited
90%
Responds within 5 days to simple rehydration or antidiarrheal agents
Typically does not require diagnostic investigation
If diarrhea persists more than 7 days, if dysentery present, or severe illness, what is the next step?
Send sample for stool studies for microbial assessment
Fecal leukocytes, Bacterial culture, O&P
positive fecal leukocytes indicates?
inflammatory
negative = inflammatory
stool cx typically detects what pathogens?
Salmonella, Shigella, and Campylobacter
May need to specify for others - E coliO157:H7
what diagnostic work-up Identifies protozoal disorders
Stool for O & P
do you need to order C. diff specifically for a stool cx?
yes
tx for acute diarrhea
- Diet
- Adequate oral hydration - Fluids containing carbs and lytes
- Bowel rest - no high-fiber foods, fats, milk products, caffeine, alc
- Frequent feedings of easily digested foods - Soup, crackers, bananas, rice, applesauce, toast (BRAT) - Rehydration
- Oral rehydration with fluids containing glucose, Na+, K+, Cl- and bicarbonate
- Convenient mixture, pedialyte, gatorade - Antidiarrheal Agents
- Loperamide (Imodium)
- Bismuth subsalicylate (Pepto–Bismol)
- Diphenoxylate / atropine (Lomotil)
receipe for a convenient mixture for rehydration
½ tsp salt
1 tsp baking soda
8 tsp sugar
8 oz. orange juice
Diluted to 1L with water
when to admit for diarrhea
- Severe dehydration
- Organ failure
- Marked abdominal pain
- Altered mental status
- Signs of hemolytic-uremic syndrome
- AKI, thrombocytopenia, hemolytic anemia
- Can be caused by severe case of E. Coli
indications for antidiarrheal agents?
- Safe with mild diarrheal illness to improve pt comfort
- Should not be used in patients with bloody diarrhea, high fever, or systemic toxicity
- d/c if diarrhea worsens despite therapy
which Antidiarrheal Agent binds to gut wall opioid receptor which inhibits peristalsis
Loperamide (Imodium)
CI of Loperamide (Imodium) - acute diarrhea
acute inflammatory diarrhea