Diarrhea Flashcards

1
Q

Things to consider when pt has diarrhea?

A
  1. Duration: acute v. chronic
  2. Consistency
  3. +/- blood
  4. location and/or travel
  5. comorbidities: IBD, IBS, GI surgery, HIV/AIDS
  6. Sick contacts
  7. Recent hospitalization
  8. Food
  9. Recent antibiotic exposure
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

for the most part, management of diarrhea is supportive and ____ is key.

A

hydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how would you know the cause of diarrhea is likely bacteria?

A

diarrhea is severe (>4 liquid stools/d x 3 d)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

______ is most critical therapy in diarrheal illnesses

A

Rehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

according to WHO, what is the preferred route of rehydration?

A

oral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

rehydration solutions consist of? (4)

A

o Sodium chloride
o Sodium bicarbonate
o Potassium chloride
o Glucose or sucrose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

products available for rehydration solutions (3)

A

o WHO-ORS
o Rehydralyte
o Cera-lyte

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

can gatorade be used as rehydration therapy?

A

no.

Watered fruit juice, Gatorade, soda are not the same and should not be considered in severe dehydration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

although there is no clinical trials to support specific diets for diarrheal illnesses, what 4 are commonly used?

A
  1. BRAT diet: Bananas, rice, applesauce, and toast.
  2. Boiled starches and cereals with salt
  3. Crackers
  4. Boiled vegetables with salt
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

should you use dairy in a diet with someone that has severe diarrhea?

A

no.

you should avoid Lactose-containing foods and High-fat foods

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antibiotics are usually not needed for diarrhea treatment unless there is a strong indication. what are these indications? (7)

A
  1. Mod-severe travelers’ diarrhea with >4 unformed stools daily, fever, blood, pus, or mucus in stool
  2. > 8 stools/d
  3. Severe volume depletion
  4. Symptoms >1 week
  5. If hospitalization is considered
  6. Immunocompromised
  7. Evidence from stool studies
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

if you suspect the diarrhea is caused by a bacteria, what antibiotic should you use to treat it?

A

ciprofloxacin or levofloxacin x 3-5 d

Alt: azithromycin or TMP-SMX x 3-5 d (Bactrim)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

When might you want to use azithromycin or TMP-SMX to treat diarrhea instead of cipro or levo?

A

If they are under 20, pregnant, etc may not want to use FQ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are 2 exceptions of diarrheal illnesses that you won’t use this standard antibiotic treatment?

A

o Enterohemorrhagic E. coli (EHEC)

o Clostridium difficile

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

should you treat the diarrhea with an antibiotic if a pt comes in with extreme diarrhea and bleeding?

A

no, it can be Enterohemorrhagic E. coli (EHEC)

  • giving them abx could kill them
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What should you do if you are treating a pt with cipro for diarrhea and find out they have c. diff?

A

Stop antibiotics and use metronidazole or PO vancomycin

17
Q

symptomatic treatment for diarrhea include what 5 medications?

A
  1. Loperamide (Imodium)
  2. Diphenoxylate + atropine (Lomotil)
  3. Bismuth subsalicylate (Pepto-Bismol)
  4. Anticholinergics
  5. Intraluminal adsorbents
18
Q

what are two antimotility agents that can be used to help treat symptoms in a pt with diarrhea?

A
o	Loperamide (Imodium)
o	Diphenoxylate + atropine (Lomotil)
19
Q

why is atropine added to diphenoxylate?

A

Diphenoxylate is structurally related to opioids, so atropine helps prevent people from abusing it

20
Q

Loperamide and Diphenoxylate + atropine are Both are analogs of_____.

A

meperidine

21
Q

can you use Loperamide or Diphenoxylate + atropine when a pt with diarrhea presents with fever or bloody stool?

A

NO

Should NOT be used with fever, bloody stool

22
Q

what are the ADRs of Loperamide and Diphenoxylate + atropine?

A

drowsiness, cramps

23
Q

how can Loperamide (Imodium) be misused?

A

o Treat symptoms of opioid withdrawal

o Euphoria

24
Q

in JUNE 2016, FDA put out what warning for Loperamide (Imodium)

A

serious/fatal cardiac arrhythmias

Mainly with use over recommended daily dose
8 mg OTC; 16 mg Rx

25
Q

on January 30, 2018, what is FDA doing to Loperamide (Imodium) to help regulate it better?

A

FDA working with manufacturers to use blister packs or other single dose packaging and to limit number of doses in a package.

26
Q

In Bismuth subsalicylate (Pepto-Bismol), what part is antisecratory?

A

subsalicylate

27
Q

In Bismuth subsalicylate (Pepto-Bismol), what part is antimicrobial?

A

bismuth

28
Q

Does Bismuth subsalicylate or Loperamide (Imodium) have a faster onset?

A

Loperamide (Imodium)

Bismuth subsalicylate has Slower onset v. loperamide

29
Q

can you use Bismuth subsalicylate (Pepto-Bismol) when a pt with diarrhea presents with fever or bloody stool?

A

YES

30
Q

what are some ADRs of Bismuth subsalicylate (Pepto-Bismol)

A

black stools, discoloration of tongue

31
Q

examples of Intraluminal adsorbents

A

clays, activated charcoal, fiber, bile acid binders