Diabetic Retinopathy Flashcards
1
Q
Describe the pathogenesis of diabetic retinopathy?
A
Chronic hyperglycaemia Glycosylation of protein/basement membrane Loss of pericytes Reduced O2 transport = tissue hypoxia Vaso-formative factors produced Neo-vascularisation Haemorrhage /scarring
2
Q
What 3 ways do diabetics lose vision?
A
Retinal oedema affecting the fovea
Vitreous haemorrhage
Scarring/tractional retinal detachment
3
Q
Describe severe non proliferative retinopathy
A
Microaneurysms plus:
>4 per quad blot haemorrhages
>2 per quad venous calibre changes
Any IRMA
4
Q
What is more important in retinopathy?
A
Severity of lesions
5
Q
What is more important in maculopathy?
A
Location of lesions
6
Q
How do we classify maculopathy?
A
No maculopathy
Observable maculoparthy
Referable maculopathy
7
Q
What is the treatment of maculopathy?
A
Lucentis (anti-vegF) injection
Occasional focal laser
8
Q
What is proliferative retinopathy?
A
New vessel formation
Vitreous haemorrhage
