Diabetic drugs

Question 1

Total daily body secretion of insulin is about…

Answer 1

40 u

Question 2

Rapid-acting insulin is a monomer that has/lacks hexamer formation and that is why it has a rapid absorption. Name some agents. O, P, DOA.

Answer 2

lacks; Aspart, lispro, glulisine. O 15m; P: 1h; D 2-4 h. It mimics the post-prandial release of insulin

Question 3

Short-acting regular insulin is/ is not a hexamer which needs to dissociate into 2 b4 absorption takes place. O, P, DOA.

Answer 3

Is; O: 30m; P: 2h; D: 8h

Question 4

NPH: o, p, doa

Answer 4

o 1h p: 8h doa: 16h

Question 5

Sulfonylureas end in :

• MOA:
• Requires what to function?
• Do not give to pts w/ ___allergy.
• Should be held ____(time) b4 sx.
• SE w/ chlorpropamide?
• Duration?

Answer 5

• ride, zide, mide
• Stimulate insulin secretion “SUmmon Insulin”
• B cell function= NOT for TYPE I DM
• Sulfa
• 24-48h
• ETOH type of s/s: flushing, N/V, hypoNa d/t vasopressin secretion.
• 7 days= hypoglycemia after d/c is possible!

Question 6

Meglitinides end in:

Answer 6

-nides

Question 7

Biguanides is:

• MOA
• SE
• Do not give to…
• Good thing about these meds!?
• M: E

Answer 7

• METformin
• Activates AMP- activated protien kinase to supress glucagon production of liver (dec genesis and inc lysis too). MEETs insulin and tells them to not come out= dec insulin exc due to ^ insulin sensitivity
• SE: lactic acidosis ( glucose met anaerobically), weight loss, vit b12 def
• Anyone @ R for met acid: CHF, hypoxemia, sepsis
• RARELY hypogly
• M: no metabolism! E: 90% kidneys

Question 8

A-glucoside inhibitors end in:

• MOA
• SE
• If combined w/ ____ and ____ can ^ R of hypogly.

Answer 8

don't match anything else!
-dec digestion and absorp of carbs
-SE: GI stuff since they act there: flatulence, diarrhea, increase ALT/AST
-Sulfonylureas and insulin
Ex. Arcabose and Migitol

Question 9

Thiozolidinediones (TZD) end in:
MOA
O
SE

Answer 9

-one
-decrease insulin resistance (^ sensitivity) and dec hepatin glucose production
-O : LONG 4-12 wks
SE: weight gain ECF; dec tryg and ^ HDL, LDL

Question 10

GLP 1 AGONIST end in:
MOA
SE

Answer 10

• tide “brings that tide of insulin!”
• INCRetIN (increase insulin): stimulate insulin secretion from b-cells, dec glucagon from a cells and reduce gastric emptying.
• SE: N/V, hypogly if mixed with sulf and insulin

Question 11

DPP4 inhibitors end in:
MOA:
Duration
Dose adj is need if ____ dz.

Answer 11

• gliptin “wants to go for that GLP but can’t”
• DPP4 degrades GLP 1…so by stopping it it cause GLP 1 to continue w/ work= incretin = ^ insulin (b cell) and dec a cell glucagon secretion
• D 12-24h
• Renal insufficiency

Question 12

AmyLIN AGONIST is

MOA

Answer 12

• pramLINtide “yes there is a TIDE in there but look for LIN”
• MOA: suppresses gastric emptying, inhibit glucagon release–DOES NOT INCREASE INSULIN LVLS