diabetic drugs

Question 1

bind insulin receptors, increase glucose stored as glycogen in liver; increase glycogen, protein synthesis, K uptake in muscle; increase TG storage in fat

Answer 1

insulin

Question 2

inhibit hepatic gluconeogenesis and the action of glucagon; decrease gluconeogenesis, increase glycolysis, peripheral glucose uptake (increase insulin sensitivity)

Answer 2

metformin

Question 3

close K channel in beta cell membrane-> cell depolarizes-> insulin release via increased Ca

Answer 3

sulfonylureas (glimepiride, glipizide, glyburide)

Question 4

increase insulin sensitivity in peripheral tissue; bind PPAR gamma nuclear transcription regulator

Answer 4

thiazolidinediones (pioglitazone, rosiglitazone)

Question 5

increase glucose dep insulin release, decrease glucagon release, decrease gastric emptying, increase satiety

Answer 5

GLP-1 analogs (exenatide)

Question 6

inhibit DPP-4 enzymes that deactivate GLP-1, thereby increase glucose-dep insulin release, decrease glucagon release, decrease gastric emptying, increase satiety

Answer 6

“-glipin”

Question 7

SE= hypoglycemia think:

Answer 7

sulfonylureas

Question 8

SE lactic acidosis

Answer 8

metformin

Question 9

SE weight gain, edema, HF, fractures

Answer 9

TZDs