Diabetes Mellitus Flashcards
Thought to be an autoimmune disease in which pancreatic beta cells are destroyed.
Not caused by lifestyle. Nothing the patient did caused this to happen.
Insulin is the only treatment for this disorder.
Type 1 DM
Adipose and muscle tissue become less sensitive to the actions of insulin or the pancreas produces less insulin than the body needs. Either one causes increased glucose levels. Most are >30 y.o. Major risk factors include: obesity and family history. Both beta cell defects and insulin resistance found in these patients.
Type II DM
pregnancy causes women to become intolerant to glucose. Screening at 24 to 28 weeks. Causes not clear. Appear to be related to the anti-insulin effects created by progesterone, cortisol, and human placental lactogen. Usually after delivery, blood glucose will return to normal. First step is always lifestyle changes. These patients are 20-50% more likely to develop DM II as they age. If mom doesn’t control sugars during pregnancy it puts her at risk for a c-section due to a large baby.
Gestational Diabetes
What is the treatment goal for DM
American Diabetes assoc says ???
American association of endocrinologist says ???
HbA1C < 7.0%
Endo <6.5%
Normoglycemia is considered HbA1C of ??? with fasting glucose of ???
HbA1C : 4-5.6%
fasting glucose of <100
oral glucose tolerance test <140
Prediabetes criteria
A1C: 5.7-6.4%
fasting plasma glucose 140-199
oral glucose tolerance test 140-199
Diabetic criteria
A1C > 6.5
fasting plasma glucose >200
oral glucose >200
anyone who has an A1C result of >6.5 should be retested to confirm diagnosis
with a positive fasting plasm for OGTT you would repeat on another day to confirm diagnosis
Treatment goals for post prandial and BP
Preprandial plasma glucose should be 80-130 mg/dL-
Postprandial plasma glucose levels should be <180 mg/dL- his is two hours after a person eats.
Blood pressure should be <140/90 mm Hg- ACE (pril) and ARB (sartan) recommended therapy for B/P!
Which drug class decreases glucose production in the liver by decreasing glucogeneogenesis and glycogenolysis which is the breakdown of glucagon to glucose
Biguanides (metformin)
It moderately improves peripheral sensitivity to insulin by increasing the peripheral glucose uptake and utilization in the muscles of the body. Glucose comes out of the blood an into the muscle for utilization.
which DM drug has no action on the pancreas and no insulin release therefore you don’t have to worry about hypoglycemia from this drug alone
Biguanides (metformin)
Metformin absorption, distribution, metabolism, excretion
taking with food can slow absorption
50-60% bioavailable
does not bind to liver, primarily excreted in kidneys, **alcohol can cause decreased lactate metabolism causing lactic acidosis (or liver disease)
Biguanides (metformin) special populations
Preg cat. B
not recommended in children < 10
use with caution in pts over 80 (risk of dehydration)
Contraindications for metformin
renal or hepatic disease, alcoholics can have increase risk for lactic acidosis
existing acute or chronic metabolic acidosis
withhold drug day of and 48 hours after iodine contrast
come side effects of metformin
GI upset, D/N/V, bloating, flatulence, metallic tast in mouth, can cause some weight loss
which two drugs are considered the only options for DM II in pediatric patients
Metformin or insulin