Diabetes Mellitus Flashcards

1
Q

Diabetes mellitus

A

a disease in which the body’s ability to produce or respond to the hormone insulin is impaired, resulting in abnormal metabolism of carbohydrates and elevated levels of glucose in the blood and urine.

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2
Q

Prevalence Among Ethnicities

A

The rates of diagnosed diabetes in adults by race/ethnic background are:
7.4% of non-Hispanic whites
8.0% ofAsian Americans
12.1% ofHispanics
12.7% ofnon-Hispanic blacks
15.1% ofAmerican Indians/Alaskan Natives

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3
Q

Complications

A

Retinopathy
Nephropathy
Cardiovascular
Neuropathy

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4
Q

Types of Diabetes

A

Type 1 – formerly known as juvenile diabetes or IDDM
Type 2 – formerly known as adult on-set diabetes or NIDDM
Gestational diabetes

There are many other lesser known types of diabetes

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5
Q

Type 1

A

Autoimmune; β cell destruction leads to absolute insulin deficiency
Insulin replacement required
“Usually” childhood/young adulthood
Changing phenotype- not always lean
~10%; increasing

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6
Q

Type 2

A

Progressive loss of insulin secretion on the background of insulin resistance
Varying degrees of pharmacologic support needed
Usually in adults
Increasingly common in youth
~90%

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7
Q

How is it diagnosed?

A

A1C ≥6.5%
FPG ≥126 mg/dL
OGTT ≥200 mg/dL
RPG ≥200 mg/dL – Only diagnostic if person presents with overt signs of hyperglycemia.
One test is not definitive. Must perform a second test to confirm unless person presents with clear clinical signs of hyperglycemia.
Testing for autoantibodies may be performed to determine whether person has type 1 or type 2.

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8
Q

Treatment Type 1

A

Insulin
Meal Planning
Exercise
Diabetes Self-management education

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9
Q

Treatment Type 2

A

Meal Planning
Exercise
Oral Medications
Insulin
Diabetes Self-management education
Injectable non-insulin medications – GLP 1 receptor agonist

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10
Q

Insulin

A

Rapid acting: Humalog, Novolog, Fiasp, Apidra
Short acting: Regular (Humulin R and Novolin R)
Intermediate acting: NPH (Humulin N and Novolin N)
Long acting: Levemir, Lantus, Toujeo
Ultra – long acting: Tresiba
Pre-mixed: Many different combinations

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11
Q

Insulin Delivery Methods

A

Vial/Syringe
Pen
Pump

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12
Q

Rapid Acting

A

Onset: 5 – 15 minutes
Peak: 1 hour
Duration: 2 – 4 hours

New Fiasp has an onset of about 2.5 minutes.

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13
Q

Regular or short acting

A

Onset: 30 minutes
Peak: 2 – 3 hours
Duration: 3 – 6 hours

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14
Q

Intermediate Acting (NPH)

A

Onset: 2 – 4 hours
Peak: 4 – 12 hours
Duration: 12 – 18 hours

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15
Q

Long and Ultra – Long Acting

A

Delivers a fairly consistent dose of insulin over 24 hours
New ultra - long acting insulin can last 42 hours. (Tresiba)

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16
Q

Pre-mixed Insulin

A

Humalog 75/25, Humalog 50/50
Humulin 70/30
Novolog 70/30
Novolin 70/30
Brand new FDA approved Xultophy: combination of Tresiba and Victoza: ultra – long acting insulin and GLP 1 receptor agonist.

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17
Q

Insulin Dosing

A

The goal is to dose insulin so it best mimics the body’s natural insulin secretion pattern.
Match dosing to carb intake

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18
Q

Basal

A

Background insulin usually taken once/day to cover in-between meals and during the night

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19
Q

Bolus

A

Meal time insulin used to cover carbs ingested during the meal. Can be given just before or immediately after consumption of meal.

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20
Q

Types of Insulin Regimens

A

Set bolus dose with meals – typically for people with type 2 diabetes
Carb (CHO) bolus to cover meals – typically 1 unit of insulin per X grams of carbs
In general terms:
l unit of mealtime insulin (lispro/aspart/apidra)
is required for every 15 grams of carbohydrate.
Insulin to carb ratio 1:15

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21
Q

Carbohydrate Counting

A

Carbs are not bad
Allows for flexibility in meal planning
Consistent and even distribution of carbs is key

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22
Q

Types of Insulin Regimens

A

Correction bolus – Amount to lower blood glucose to target

Correction Scale: Give units of insulin for each interval of BG
Example: 1 unit 150-200, 2 units 201-250, 3 units 250+
Correction factor: Blood glucose level – target blood glucose/correction factor = units insulin to be given
Example: BG=150 (actual) minus Target BG (100) = 50 divided by Correction factor (50) = 1 unit insulin needed

23
Q

Where to inject?

A

Must be administered subq
Abdomen, thigh, buttocks, upper arms are common sites
Need to rotate sites to prevent lipohypertrophy (hard fatty lumps)
Insulin is best absorbed from areas in the following order: abdomen, upper arms, thigh, buttocks

24
Q

Mixing insulin

A

Mixing insulin must be done in a specific order. Do not mix long acting insulin with any other type of insulin. Can only mix short or rapid (clear) with NPH (cloudy)
NPH will separate. Make sure it is uniformly cloudy before mixing. Gently roll the bottle between your hands. DO NOT SHAKE!

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Mixing insulin steps
1st – Inject air into the NPH. Make sure bottle is NOT inverted 2nd – Inject air into clear or rapid insulin 3rd – Invert bottle and draw up correct amount of insulin 4th – Without moving the plunger, insert syringe into NPH and draw up correct amount of insulin
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Exercise
Exercise is good for everyone. Person needs to understand how different types of exercise affects their body. Generally exercise will lower blood glucose levels Exercise may continue to lower blood glucose levels up to 24 hours after completion of activity.
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When things don’t go as planned
Hypoglycemia: Blood glucose level below 70 Hyperglycemia: Blood glucose level above target value. In the hospital we generally set a target of 140 – 180.
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Hyperglycemia
Onset: Usually slow to develop to severe levels More rapid with pump failure/malfunction, illness, infection Can mimic flu-like symptoms Greatest danger: may lead to diabetic ketoacidosis (DKA) if not treated Severe Symptoms      Labored breathing  Confusion Profound weakness  Unconscious Moderate Symptoms Dry mouth Vomiting Stomach cramps  Nausea Mild Symptoms Lack of concentration Thirst Frequent urination Flushing of skin Sweet, fruity breath Blurred vision Weight loss Increased hunger Stomach pains Fatigue/sleepiness
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Hyperglycemia causes
Late, missed or too little insulin Food intake exceeds insulin coverage Decreased physical activity Expired or improperly stored insulin Illness, injury Stress Other hormones or medications Hormone fluctuations, including menstrual periods Any combination of the above
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Hyperglycemia treatment
Lower blood glucose down to target range Verify with blood glucose check Check ketones Administer insulin Administer fluids Recheck blood glucose
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Hypoglycemia
Onset: sudden, must be treated immediately may progress to unconsciousness if not treated can result in brain damage or death
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Hypoglycemia causes
Too much insulin Too little food or delayed meal or snack Extra/unanticipated physical activity Illness Medications Stress
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Hypoglycemia treatment
Based on severity of hypoglycemia Mild – Moderate Moderate – Severe Severe
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Hypoglycemia symptoms
Mild Symptoms Hunger  Sleepiness Shakiness  Changed behavior Weakness  Sweating Paleness  Anxiety Blurry vision  Dilated pupils Increase heart rate or palpitations Moderate to Severe Symptoms        Yawning Confusion Irritability/frustration Restlessness Extreme tiredness/fatigue Dazed appearance Inability to swallow Unconsciousness/coma Sudden crying Seizures
35
Treatment - Hypoglycemia
Remember the “Rule of 15” If person is able to safely swallow – give 15 grams of CHO, wait 15 minutes and check BG a second time. If BG still < 70 then treat again with 15 gm of CHO. If still < 70 after treating x2, call the physician or 911 if outside of the hospital. Continue to treat until help arrives. If >70, have person eat something with carbohydrate, protein and fat to sustain level. If person is unable to swallow safely then you will need to treat with glucagon or IV dextrose. Glucagon can be given subq or IM Clean site if possible. Inject at 90° into the tissue under cleansed area (may administer through clothing as necessary buttocks thigh Arm First pre-mixed glucagon injection- ages 2 yrs and up
36
BAQSIMI (BAK-see-mee)
It is also known as glucagon nasal powder. It is not known if BAQSIMI is safe and effective in children under 4 years of age. Should be given in a low blood sugar emergency, even if you have passed out, because BAQSIMI does not need to be inhaled. Must roll person on to side after administration. Left side if preferred but either side will do. Examples of 15 gm of CHO – 4 ounces of Juice 15 raisins (small package) 8 ounces of milk 3 or 4 glucose tablets ---person may have hypoglycemic unawareness Hyperglycemia is treated with insulin
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Target Goals - Adults
Blood glucose: 70 – 130 (home) 140 – 180 (in hospital) Blood pressure: < 140/90 Triglyceride: ≤ 150 HDL: > 40 males > 50 females A1C: < 7%
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Angiopathy
Damage to blood vessels secondary to chronic hyperglycemia (Fig. 48-14 in the textbook) Leading cause of diabetes-related death 68% CVD and 16% stroke age 65 and older Two categories: macrovascular and microvascular complications Long-term complications are devastating; require ongoing monitoring. See Table 48-20 in the textbook for ADA recommendations Annual exam: Retinopathy, nephropathy, neuropathy (comprehensive foot exam), cardiovascular risk factor assessment As needed or every visit to HCP: Foot and lower extremity exam, exercise stress testing Daily Foot exam by patient
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Macrovascular Angiopathy
Diseases of large and medium-sized blood vessels Cerebrovascular disease Cardiovascular disease Peripheral vascular disease Greater frequency and earlier onset in patients with diabetes Women 4 to 6x risk for CVD Men 2 to 3x risk for CVD than nondiabetics Decrease and treat CVD risk factors Obesity—nutrition and exercise Smoking—blood vessel disease, stroke and lower extremity amputation; cessation Hypertension—optimize BP;  CV and renal disease High fat intake/dyslipidemia; statin and lifestyle interventions Sedentary lifestyle—exercise
40
Microvascular Complications
Thickening of vessel membranes in capillaries and arterioles from chronic hyperglycemia Areas most affected: Eyes—retinopathy Kidneys—nephropathy Nerves—neuropathy
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Retinopathy
Microvascular damage to retina due to chronic hyperglycemia, nephropathy, and HTN Most common cause of new cases of adult blindness
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Retinopathy: Interprofessional Care
Initially no changes in vision Annual eye examinations with dilation to monitor Maintain healthy blood glucose levels and manage hypertension
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Nephropathy
Damage to small blood vessels that supply the glomeruli of the kidney Leading cause of end-stage renal disease in U.S.; 20% to 40% of people with diabetes have it Risk factors Hypertension Genetics Smoking Chronic hyperglycemia Annual screening for albuminuria and albumin-to-creatinine ratio If albuminuria present, drugs to delay progression: ACE inhibitors or angiotensin II receptor antagonists Control of hypertension and blood glucose levels in a healthy range: imperative
44
Neuropathy
Nerve damage due to metabolic imbalances of diabetes 60% to 70% of patients with diabetes have some degree of neuropathy Sensory neuropathy—most common
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Neuropathy
Nerve damage due to metabolic imbalances of diabetes 60% to 70% of patients with diabetes have some degree of neuropathy Sensory neuropathy—most common
46
Neuropathy: Etiology and Pathophysiology
Reduced nerve conduction and demyelination Ischemic damage to peripheral nerves May precede, accompany, or follow diagnosis Classifications: sensory or autonomic
47
Sensory Neuropathy
Paresthesias— tingling, burning, itching; “walking on pillows or numb feet;” Very sensitive Complete or partial loss of sensitivity to touch or temperature is common Small muscles of hands and feet may be affected causing deformity and limited fine movement
48
Sensory Neuropathy- treatment
Managing blood glucose levels Drug therapy Topical creams Tricyclic antidepressants Selective serotonin and norepinephrine reuptake inhibitors Antiseizure medications
49
Autonomic Neuropathy
Can affect nearly all body systems and lead to: Hypoglycemic unawareness, bowel incontinence and diarrhea, and urinary retention Gastroparesis Cardiovascular abnormalities Sexual function Erectile dysfunction—often first manifestation Decreased libido Vaginal infections Neurogenic bladder can cause urinary retention
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Foot and Lower Extremity Complications
Sensory neuropathy and PAD are major risk factors. Other factors: clotting abnormalities, impaired immune function, autonomic neuropathy Smoking increases risk Sensory neuropathy may cause loss of protective sensation (LOPS) prevents awareness of injury; major risk factor for amputation Annual monofilament screening Peripheral artery disease (PAD) Decreased blood flow = decreased O2, WBCs, and nutrients causes longer wound healing, increased risk for infection Patient teaching: Foot care (Table 48-21 in the text) Proper footwear Avoidance of foot injury Skin and nail care Daily inspection of feet Prompt treatment of small problems Diligent wound care for foot ulcers Neuropathic arthropathy (Charcot’s foot) Joint dysfunction and footdrop may cause ulcers
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Skin Complications
Diabetic dermopathy—most common Red-brown, round or oval patches Scaly then flat and indented; shins Acanthosis nigricans—manifestation of insulin resistance Velvety light brown to black skin thickening; flexures, axillae, and neck
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Infection
Defect in mobilization of inflammatory cells and impaired phagocytosis Recurring or persistent infections Antibiotics—prompt and vigorous Patient teaching to prevent infection Hand hygiene, avoid exposure Flu and pneumococcal vaccine COVID vaccine
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Psychologic Considerations
High rates of depression, anxiety, and eating disorders Diminished self-care, helplessness, and poor outcomes Diabetes distress—stress, fear, and burden of living with and managing diabetes Disordered eating behaviors (DEB) Anorexia, bulimia, binge eating, excessive calorie restriction, and intense exercise
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Gerontologic Considerations
Increased prevalence and mortality Present in 25% over age 65 due to -cell function, decreased insulin sensitivity, and altered carbohydrate metabolism Glycemic control challenging Increased hypoglycemic unawareness Functional limitations Coexisting medical problems Cognitive decline