Diabetes Meds Flashcards
What should you not give the TZDs with (which disease)?
Heart failure
How often do you test for DM?
Annually for BMI 25 and one other risk factor
Entire population greater than 45 every three years if normal
What medications are SGLT2 inhibitors?
-gliflozin- invokana
What do thiazolidinediones do?
Preserves beta cell function, improves insulin response of cells
What’s the MOA of GLP-1 Agonists?
glucagon like peptide, increases production of insulin in response to elevated BG level
Goals for DM?
Most adults <7
Older <8
Type 1 and pregnant <6
What medications are in sulfonulurieas?
Glimepiride, glipizide, glyburide
What do DDP-4 agents do?
Increases release of uncertain, and decreases release of glucagon
What medications are GLP-1 Agonists?
-TIDEs, victoza
What medical condition is associated with the use of exantide (DLP 1 agonist)?
Pancreatitis
How much do DPP-4 reduce A1C?
.7%
What is pioglitazone associated with?
Bladder cancer
What medication is a biguanide?
metformin
How much to sulfonylureas reduce A1C?
1-2%
How much do the thiazolidinediones reduce A1C?
.7%
What do the SGLT2 inhibitors do?
prevent reabsorption of renal glucose, increases glucose excretion
What are thiazolidinediones contraindicated in?
heart failure
What medication is a DPP-4 inhibitor?
Gliptins (Januvia)
What medications are TZDs?
-glitazones, rosiglitazone
What is the MOA of sulfonylurea?
potentiate insulin secretion
What disease is GLP-1 contraindicated in?
gastroparesis
How much do GLP-1 Agonists reduce A1C?
1-1.5%
What else is a good benefit for GLP-1 Agonists?
Weight loss of 2-6 pounds in a year
What medications are in the DPP-4 category?
Gliptins
BMI cut off for adults with one or more risk factors for DM?
25
What are high doses of thiazolidinediones associated with?
Bone fractures, osteopenia
