Diabetes in Pregnancy Flashcards

1
Q

What is type III diabetes?

A

Gestational/pregnancy developed diabets

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2
Q

What percentage of diabetes in pregnancy is GDM?

A

85%

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3
Q

Risk factors for gestational diabetes:

A

-advanced maternal age (>= 35; higher risk >=40)
-previous infant >9 lbs
-prepregnancy BMI > 30
-Hx GDM (40-50% recurrence)
-HbA1C > 5.7
-hx adverse obstetric outcome associated with GDM

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4
Q

What are the 2 biggest risk factors of gestational diabetes?

A

-Hx GDM (40-50% recurrence)
-HbA1C > 5.7

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5
Q

Who gets screened?

A

everyone! Universal screening is performed.

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6
Q

When does universal screening occur?

A

24-28 weeks

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7
Q

What test is performed for initial screening?

A

50 gram 1 hours glucose challenge

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8
Q

What is considered ABNORMAL for 1 hour 50 g glucose challenge

A

> 130 (80% sensitivity)
140 (90% sensitivity)

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9
Q

What is the next step for glucose testing after a failed 1 hour?

A

3 hours 100 gram challenge

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10
Q

What are the parameters for 100 g 3 hour test?
-fasting
-1 hr
-2 hr
-3 hr

A

fasting > 95
1 hr > 180
2 hr > 155
3 hr > 140

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11
Q

How many parameters must you fail in the 3 hour to be diagnosed with GDM?

A

2

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12
Q

How do you target underlying type II diabetes

A

-HbA1C > 5.7%
-GDM previous pregnancy
-Hx cardiovascular disease
-Htn
-HDL<35 Triglyceride >250
-PCOS
-First degree relative, physical inactivity, high risk ethnic group

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13
Q

Pregnancy risks with gestational diabetes

A

-LGA
-Macrosomia (>4500 mg)
-increased risk operative delivery
-shoulder dystocia
-brachial plexus injury
-increased risk C/S

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14
Q

What occurs when the mothers blood brings extra glucose to the fetus?

A

-fetus makes more insulin to handle excess sugar
-extra glucose gest stored as fat and fetus becomes larger than normal

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15
Q

What are risks to the birthing mom with GDM?

A

-hypertension
-preeclampsia
-birth trauma

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16
Q

What are the risks to the baby? (metabolic complications)

A

-hypoglycemia
-hypocalcemia
-hyperbilirubinemia

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17
Q

How do you treat GDM? First line

A

-Personalized meal plan (35-40% carbs, 20% protein, 40% fat)
-moderate exercise
-nutritional consult

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18
Q

If unable to get GDM in control with lifestyle modifications then step 2:

19
Q

Blood glucose monitoring goals
-fasting
-postprandial (1 and 2 hr)

A

fasting <95
1 hr <140
2 hr <120

20
Q

What is A1 GDM? A2?

A

A1: able to be controlled with diet & exercise
A2: medication involved

21
Q

A2 prenatal care plan
Antenatal testing? Delivery suggestions?

A

-weekly antenatal testing begins at 32 weeks
-deliver 39-40 weeks
-consider C/S if estimated fetal weight (EFW) is > 4,500 grams

22
Q

Postnatal care?
-testing

A

Perform the 75 gram f2 hr oral glucose challenge at 6 weeks postpartum
-Diabetes screening annual for 5-10 years

23
Q

What is the risk of future DM in a pt that had GDM?

A

50-70% increased risk

24
Q

What can increase the risk of recurrence of GDM?

A

A Short interval - encourage contraception!

25
Pregestational diabetes: - normal fasting vs. DM fasting - normal 50 g 1 hr vs. DM
Normal <110 DM >126 Normal 50 g 1 hr <140; DM > 200
26
Preconception counseling for individuals with pregestational diabetes
-immunization: rubella -screening: HIV, RPR, HBSAg, CF -prenatal vitamins -age related risk -fetal risks -maternal risks
27
Fetal risks - pregestational diabetes
-miscarriage -congenital malformations: remember orgnogenesis is done by 9 weeks EGA - NO increased risk of anueploidy -macrosomia ~ increases risk of birth trauma -intrauterine growth restriction
28
Specific congenital anomalies - pregestational diabetes
Cardiac: VSD (ventricular septal defect) CNS: anencephaly; spina bifida
29
Diagnosis of intrauterine growth restriction
baby is at <10th percentile of the birthweight
30
Pregestational diabetes: preterm delivery | Etiologies (contributors)
-polyhydramnios -preeclampsia -poor glycemic control -worsening nephropathy
31
Perinatal risk: pregestional diabetes | what could go wrong during labor
-hyperbilirubinemia -hypoglycemia -respiratory distress -hpocalcemia -cardiomyopathy -polcythemia -hypothermia
32
Pregestional diabetes: maternal cardiovascular risks
-Chronic htn: stroke, preeclampsia, placental abruption -Coronary artery disease (CAD) -Preeclampsia
33
Pregestaional diabetes: maternal renal risks
-Nephropathy: increases risk of preeclampsia [increases risk of preterm delivery and IUGR] -GFR is impaired in 67% diabetic pregnancies -increased risk UTI
34
# Pregestional diabetes Maternal ocular risks
retinopathy -unlikely to develop during pregnancy -if present before, it often worsens -usually transient -laser therpy is effective
35
# Pregestational diabetes Maternal nueropathy
peripheral neuropathy -does not get worse with pregnancy autonomic neuropathy -does not worsen
36
# Pregestational diabetes Maternal nueropathy: what autonomic risks increase?
-hyperemesis -hypoglycemia unawareness -orthostatic hypotension -urinary retention
37
# Pregestational diabetes Prenatal evaluation: labs!
-Routine labs (Pcp, Hct, T&S) -Hgb A1C -BUN, Cr -Urinalysis -24 hours urine -TSH -Blood pressure -EKG -Eye exam | anything that the small vessels are a big part of*
38
# Pregestational Diabetes Prenatal care: First trimester U/S
-confirm EDC -verify viability
39
# Pregestational Diabetes Prenatal care: Second trimester U/S
-evaluate for congenital malformations
40
# Quick reminder on peak and duration of insulin: -Humalog (lispro) -Regular -NPH -Glargine
-Humalog: peak 1 hr; duration 2 hr -Regular: peak 2 hr; duration 4 hr -NPH: peak 4 hr; duration 8 hr -Glargine: peakless; duration 20 hr
41
# Pregestational diabetes Fetal surveillance
-fetal kick counts -ultrasound -weekly antenatal testing
42
# Pregestational diabetes Prenatal care: fetal surveillance - when to begin: -fetal kick count -ultrasound -weekly antenatal testing
-fetal kick count: after 28 weeks -US: every 4 weeks after 28 weeks -Weekly antenatal testing: from 32-36 weeks
43
Pre-gestational diabetes -Normal fasting/50G -Impaired fasting/50G -DM fasting/50G
-Normal fasting/50G: <110/<140 -Impaired fasting/50G: 110-126/140-199 -DM fasting/50G: >126>200