Diabetes drugs- Incretin drugs

Question 1

Incretin analogues-1 (3)

Answer 1

extenatide and liraglutide

are peptides that mimic the action of GLP-1 but resist breakdown by DPP-4

Question 2

Incretin analogues -2

Answer 2

agonists of GPCR GLP-1 receptors that increase intracellular cAMP concentration in pancreatic β-cells to stimulate insulin expression and release

Question 3

Incretin analogues -3 (3)

Answer 3

suppress glucagon secretion
slow gastric emptying
decrease appetite (hypothalamic action)

Question 4

Incretin analogues side effects (4)

Answer 4

modest weight loss
reduce hepatic fat accumulation
nausea
rarely pancreatitis