Diabetes drugs Flashcards

1
Q

METFORMIN

A
  • Weight neutral, reduces insulin sensitivity, no hypos, cardioprotective.
    • Not used in kidney impairment - egFR under 45 reduce, eGFR stop it.
    • Causes bloating, diarrhoea, indigestion.
      FIRST LINE
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2
Q

Sulfonylurea

A
  • Weight gain, increase insulin SECRETION- helping you absorb calories.
    • Causes HYPOS and weight gain.
    • Works quickly!! ‎Glimepiride
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3
Q

DDP4 = Gliptins

A

Increasing insulin secretion.
Don’t use if someone’s had pancreatitis before (increase pancreas risk)
Weight neutral. Lower risk of HYPOS.
“GLIP-ancreatitis “

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4
Q

Glitazones - Pioglitazones.

A

(piolitazones PILE on the weight).
Reduces resistance. Weight gain.
Don’t use in cardio problems. Avoid in bladder issues.
Don’t use if got osteoporotic fracturs.

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5
Q

SGLT-2s

A
Canigiflosin, impagliflosin. 
UTIS and thrush Lose weight
Helps prevent heart failure. 
Reno-protective. 
Don’t take when feeling unwell or egFR under 60 or type 1.
SuGar Through wee
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6
Q

GLP-1

A
GLP-1 
Reduce weight. Increase insulin resistance.
Make feel sick. Cardioprotective.
Expensive. 
Good data - not comparable.
Gastric empting Prolonged
GLP-1 = pancreatitis
DDP-4 = Pancreatitis
DDP-ancreatitis
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7
Q

magic numbers for diabetes

A

48-53-58 for drugs

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8
Q

HBA1C

A

BA1C 42-47, = impaired glucose tolerance. 47+ is diabetes.
Cant do in pregnancy, type 1 and haematological disorder or renal anaemia or hyposplenism. Have higher turnover, people transfused regularly.

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9
Q

random blood glucose

A

< 7 is normal, 7-11 is borderline, 11+ is diabetes

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10
Q

FBG Fasting blood glucose =

A

< 6 normal, 6-7 pre-diabetic, > 7 is diabetic.

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