Diabetes Drugs

Question 1

What are “mides + zides”

Answer 1

Suphonylureas

Question 2

What side effects so sulphonylureas “mides and zides” have?

Answer 2

hypos
weight gain
avoid in pregnancy

Question 3

what are tides?

Answer 3

GLP-1 Receptor Agonists

Question 4

What side effect do GLP-1 Receptor Agonists “tides” have?

Answer 4

GI upset

Avoid in pregnancy

Question 5

How do Sulphonylureas work?

Answer 5

promote insulin secretion (B cells)

Question 6

How do GLP-1 Receptor Agonists and DPP4-Inhibitors work?

Answer 6

promote insulin secretion

Question 7

How does metformin work?

Answer 7

inhibits gluconeogenesis

Question 8

side effects of metformin

Answer 8

GI upset

stop if eGFR <30

Question 9

Insulin side effects

Answer 9

hypos

weight gain

Question 10

Which diabetes drugs are good for weight loss?

Answer 10

GLP-1 Receptor Agonists and SGLT2 inhibitors

Question 11

DPP4 - inhibitors side effects

Answer 11

not safe in pregnancy

Question 12

what are gliptins?

Answer 12

DPP4-inhibitors

Question 13

What are gliflozins?

Answer 13

SGLT2 Inhibtors

Question 14

how do SGLT2 inhibitors work?

Answer 14

increase Na+ and glucose excretion

Question 15

SGLT2 side effects

Answer 15

not safe in pregnancy

Question 16

What are glitazones?

Answer 16

Thiazolidinediones (TZDs)

Question 17

TZD side effects?

Answer 17

weight gain

not safe in pregnancy

Question 18

Which T2DM drugs do you need to stop the day of surgery?

Answer 18

metformin (omit one dose)
sulphonylureas “zides and mides”
SGLT2 inhibitors “gliflozins”

Question 19

Which T2DM drugs do you continue the day of surgery

Answer 19

GLP-1 Agonists “tides”
DPP4 - inhibitors “glipitins”
TZDs

Question 20

How is insulin dosing changed for surgery?

Answer 20

reduce long acting dose by 20% the day before an day off
omit morning short acting insulin
start on sliding scale (variable rate IV infusion)