Diabetes Drugs Flashcards
What are “mides + zides”
Suphonylureas
What side effects so sulphonylureas “mides and zides” have?
hypos
weight gain
avoid in pregnancy
what are tides?
GLP-1 Receptor Agonists
What side effect do GLP-1 Receptor Agonists “tides” have?
GI upset
Avoid in pregnancy
How do Sulphonylureas work?
promote insulin secretion (B cells)
How do GLP-1 Receptor Agonists and DPP4-Inhibitors work?
promote insulin secretion
How does metformin work?
inhibits gluconeogenesis
side effects of metformin
GI upset
stop if eGFR <30
Insulin side effects
hypos
weight gain
Which diabetes drugs are good for weight loss?
GLP-1 Receptor Agonists and SGLT2 inhibitors
DPP4 - inhibitors side effects
not safe in pregnancy
what are gliptins?
DPP4-inhibitors
What are gliflozins?
SGLT2 Inhibtors
how do SGLT2 inhibitors work?
increase Na+ and glucose excretion
SGLT2 side effects
not safe in pregnancy
What are glitazones?
Thiazolidinediones (TZDs)
TZD side effects?
weight gain
not safe in pregnancy
Which T2DM drugs do you need to stop the day of surgery?
metformin (omit one dose)
sulphonylureas “zides and mides”
SGLT2 inhibitors “gliflozins”
Which T2DM drugs do you continue the day of surgery
GLP-1 Agonists “tides”
DPP4 - inhibitors “glipitins”
TZDs
How is insulin dosing changed for surgery?
reduce long acting dose by 20% the day before an day off
omit morning short acting insulin
start on sliding scale (variable rate IV infusion)
