Diabetes Flashcards
Long term complications of DM
- Blindness
- ESRD
- Non-traumatic lower limb amputation
What is DM a major risk factor for?
- Heart disease
- Stroke
- HTN
- High cholesterol
Functions of insulin
- Transports & metabolizes glucose for energy
- Stimulates storage of glucose in liver
- Signals liver to stop release of glycogen
- Enhances storage of dietary fat & adipose tissue
- Accelerates transport of amino acids into cells
- Inhibits breakdown of stored glucose, protein, fat
What causes glycosuria?
Concentration of glucose is > 180-200 —> kidneys cannot reabsorb all the glucose & it is excreted in urine
What accompanies glycosuria?
Excessive loss of F&E
Osmotic diuresis
Loss of glucose in urine —> excessive loss of F&E
Components of metabolic syndrome
If pt has 3/5 = metabolic syndrome —> increased risk of heart disease, DM, stroke
- Elevated glucose
- Abdominal obesity
- Elevated BP
- High triglycerides
- Decreased HDL
When can DKA occur in type 2?
Severe illness or stress when pancreas cannot meet extra demand for insulin
Risk factors for type 2
- Obesity
- Age
- Previous impaired fasting glucose or glucose tolerance test
- HTN
- HDL < 35
- Triglycerides > 250
- HX of gestational DM or baby > 9 lbs
Clinical manifestations
- Polyuria, polydipsia, polyphagia
- Fatigue, weakness
- Vision changes
- Tingling/numbness of hands & feet
- Dry skin, skin lesions or wounds that won’t heal
- Recurrent infections
- Type 1 may have sudden weight loss
Diagnostic criteria
- Fasting glucose 126 or more
- Casual glucose exceeding 200
- S/S
3 main causes of DKA
Severe deficiency of insulin
- Decreased or missed dose
- Illness or infection
- Undiagnosed or untreated DM
What may be the initial manifestation of type 1?
DKA
DKA is commonly preceded by a day or more of…
- Polyuria
- Polydipsia
- N/V (S/T acidosis)
- Fatigue —> eventual stupor & coma if not treated
- Acetone breath
Clinical features of DKA
- Hyperglycemia
- Dehydration w/electrolyte loss
- Acidosis
How much water & electrolytes can be lost due to DKA?
- 6.5 L water
- 400-500 mEq EACH of Na, K, Cl