Diabetes Flashcards
Diabetes Mellitus (definition)
Disorder of hyperglycemia resulting from defects in insulin secretion, insulin action, or both, leading to abnormalities in carbohydrate, protein, and fat metabolism
Pancreas (function)
Produce hormones necessary for the metabolism and cellular utilization of carbs, proteins, and fats
Alpha Cells
Produce the hormone glucagon > stimulates the breakdown of glycogen by the liver (increase blood glucose levels)
Glycogenolysis
Breakdown of liver glycogen
Gluconeogenesis
Formation of glucose from fats and proteins
Beta Cells
Secrete insulin; lowers blood glucose when it becomes too high
Delta Cells
Produce somatostatin (believed to inhibit both production of glucagon and insulin)
Type 1 DM
- Involves the destruction of beta cells (which produce insulin)
- Usually occurs at a young age
Type 2 DM
- Insulin resistance
- Occurs later in life due to obesity, inactivity and heredity
Type 1 DM (S/S)
- Hyperglycemia (and development of ketosis)
- Polyuria
- Glucosuria
- Polydipsia
- Polyphagia (but no weight gain)
- Weight loss (as the body loses water and breaks down proteins and fats in an attempt to restore energy sources)
- Malaise, fatigue
Type 2 DM (S/S)
- Hyperglycemia
- Polyuria
- Polydipsia
- Blurred vision
- Fatigue
- Paresthesias
Type 2 DM (risk factors)
- History of diabetes in parents or siblings
- Obesity
- Physical inactivity
- Race/ethnicity
- Women (gestational diabetes, or delivering baby weighing more than 9lbs)
- HTN
- High triglyceride levels
- Metabolic syndrome
Dawn Phenomenon
- Rise in blood glucose between 4am-8am that is not a response to hypoglycemia
- Occurs in both Type 1 and 2 DM
Somogyi Phenomenon
Combo of hypoglycemia during the night with a rebound morning rise to hyperglycemic levels
Diabetic Ketoacidosis (DKA)
Develops when there is an absolute deficiency in insulin and an increase in the insulin counterregulatory hormones -> ketogenesis is stimulated