DIABETES Flashcards
Definition of Diabetes
Diabetes is a chronic disorder of metabolism with serious consequences.
Two main types: Type 1 and Type 2
Type 1 Diabetes
8-10% of the population.
Characterized by deficient insulin production.
Requires daily insulin.
Type 2 Diabetes
90% of the population.
Involves ineffective use of insulin.
Also known as adult-onset diabetes or non-insulin dependent
Insulin Function
Insulin receptors facilitate upregulation of glucose transporters.
Allows glucose into cells.
Regulates blood glucose levels.
Beta cells and islets of Langerhans essential in insulin production.
Induces glucose storage in the liver, muscles, and adipose tissue
Symptoms of Diabetes
thirst (polydipsia).
Increased blood sugar levels (hypoglycemia).
Stomach pain and constant hunger.
Slow wound healing.
Excessive urination (polyuria).
Weight loss.
Fatigue/sleepiness.
Blurred vision.
Polyphagia (constant hunger).
Tests to Diagnose Diabetes
Fasting glucose test.
Non-fasting.
Oral glucose tolerance test.
HbA1c test.
C-peptide test.
Non-Modifiable Risk Factors for Type 2 Diabetes
Age.
Ethnicity.
Gender.
Family history
insulin Resistance
Distinguishes Type 1 and Type 2.
Best tested with euglycemic hyperinsulinemic clamp.
Less insulin clears blood.
Liver less effective at suppressing hepatic glucose production
Modifiable Risk Factors for Type 1 Diabetes
lifestyle
Managing Diabetes
Medication.
Access to insulin.
Blood glucose control.