Diabetes Flashcards
The primary organ involved in diabetes mellitus is the?
Pancreas
What is the abbreviation for hyperosmolar hyperglycemic state?
HHS
Where is the pancreas located?
Behind the stomach between the spleen and the duodenum.
Describe the two functions of the pancreas
1) Acini cells secrete digestive enzymes into the duodenum.
2) the Islets of Langerhans release insulin and glucagon.
What is hyperglycemia?
High blood glucose level
What is hypoglycemia?
Low blood glucose level
What two hormones must be balanced to prevent hypoglycemia and hyperglycemia?
Insulin and glucagon
What cells in the Islets of Langerhans produce insulin?
Beta cells
The primary function of insulin is to
Regulate blood glucose levels
How does insulin regulate blood glucose levels?
Insulin eases the active transport of glucose into muscle and fat cells
Insulin facilitates
Fat formation
Complete the sentence
Insulin inhibits the breakdown and movement of __________ _________
Stored fat
Insulin helps move amino acids into cells for?
Protein synthesis
Glucose unused by the cells stored in the liver and muscle cells are known as
Glycogen
Complete the sentence
If there is excess glucose it is converted into fat and stored as __________ ________
Adipose tissue
When does insulin release increase?
When blood glucose level rise
When does insulin levels decrease?
When blood glucose levels fall
Fill in the blank
When a person eats food, insulin levels rise in minutes, peak in ___ to 60minutes, and return to baseline in _____ to ______ hours
Peak 30-60 minutes, baseline 2-3 hours
What cells in the islets of Langerhans produce glucagon?
Alpha cells
Glucagon prevents blood glucose from?
Decreasing when the body is fasting or between meals
Define gluconeogenesis
When glucagon makes new glucose
Define glycogenolysis
When glucagon converts glycogen into glucose in the liver and muscle
Complete the sentence
Glucagon _______ excess glucose breakdown
Prevents
Complete the sentence
The primary function of glucagon is to _______ glucose oxidation and to ______ blood glucose
Decrease, increase
Glucagon is released when blood glucose falls below
70 mg/dL
Explain what Counter-regulatory hormones are
Hormones that help increase glucose levels.
List some examples of counter regulatory hormones
Epinephrine, growth hormone, and cortisol
Normal blood glucose is maintained in healthy people through a balance of actions between?
Insulin and glucagon
According to SMH and the Burke textbook normal blood glucose is defined as
70 to 110 mg/dL
Refer to Figure 34-3 on page 883 and complete the paragraph.
When there is high blood glucose in the body the pancreas releases _____. This causes the cells to take up _____ from the blood or the liver to produce _______. This allow the blood glucose to fall.
When there is high blood glucose in the body the pancreas releases INSULIN. This causes the cells to take up GLUCOSE from the blood or the liver to produce GLYCOGEN. This allow the blood glucose to fall.
Refer to Figure 34-3 on page 883 and complete the paragraph
When there is low blood glucose the pancreas releases ______ which makes the liver break down __________ causing the blood sugar to rise.
When there is low blood glucose the pancreas releases GLUCAGON which makes the liver break down GLYCOGEN causing the blood sugar to rise.
List the three laboratory tests for the pancreas
Fasting blood glucose, glycosylated hemoglobin (HbA1c), and two hour oral glucose tolerance test (OGTT)
What are the normal values for the glycosylated hemoglobin test? (HbA1c)
5.5% to 7%
What are the normal lab values for the two hour oral glucose tolerance test? (OGTT)
Less than 125mg/dL
What test determines the level of glucose 2 hours after drinking 75g of glucose?
Two hour oral glucose tolerance test (OGTT)
What test is uses to measure glucose control during the previous 3 months and is not used to diagnose diabetes mellitus.
Glycosylated hemoglobin (HbA1c)