Device Based Therapy

Question 1

CARE-HF (2005)

Answer 1

CRT on M&M

• Class III or IV, LV dysfxn, QRS >150 or 120-149+echo dyssinchfony
• Decreased Death/Hosp for CV
• Better echo parameters, QOL

Question 2

CHAMPION (2011)

Answer 2

CARDIOMEMS

• NYHA III, both rEF+pEF
• Decreased readmissions, need DAPT 1m or A/c.

Question 3

COMPANION (2004)

Answer 3

CRT w/wo ICD CII-IV, ICM+NICM

- 40% dec CRT-D vs CRT

Question 4

DANISH (2016)

Answer 4

Defib in NICM

• EF<35%
• No difference in Primary, Death
• Decrease in SCD

Question 5

DINAMIT (2004)

Answer 5

ICD 6-40d post MI (prophylactic)

• No diff in mortality
• Inc non-arryth death vs dec arrythmic death

Question 6

MADIT CRT (2009)

Answer 6

CRT-D HFrEF

• II-III, ICM+NICM, QTS>130,
• Dec comp death/HF events
• DEC HF events, no diff death

Question 7

MADIT 2 (2002)

Answer 7

Proph ICD for MI+rEF

- Dec mortality

Question 8

SCD-HEFT

Answer 8

AMIO vs ICD EF<35%, CII-CIV

• Mortal dec in ICD
• ONLY TRIAL INCLUDING NICM

Question 9

CardioMEMS Post approval

Answer 9

58% reduction in HFH, & a 28% reduction rate in all cause hospitalizatioin at 1 year.

Question 10

MUST

Answer 10

ICM ef<40% and NSVT

EPS guided study to ICD+AAD
IMPROVED CARDIAC ARREST+Arryrhmic death
No

Question 11

MADIT 1

Answer 11

ICM, hfref <35%, documented NSVT!!

Improved mortal